Aim. Antimicrobial resistance among Gram-negative bacteria is a worldwide problem. Antibiotic resistance is a natural adaptation of bacteria in an environment full of antibiotics, especially in the hospital settings. Bacterial resistance may occur in the hospital under pressure of antibiotics or be acquired from other healthcare settings before admission. Multiresistant bacteria can easily spread in the hospital or become endemic in some departments (usually in the intensive care unit). The main problems with carbapenems resistant bacteria have been observed throughout the great limitations of antimicrobial therapy. Carbapenemase-producing isolates, mostly from intensive care, are among the most multiresistant nosocomial bacteria known and are often susceptible only to polymyxins and tigecycline. Carbapenem producing bacteria are usually identified in enterobacteria (Klebsiella, Escherichia, Enterobacter).

Data on the prevalence of carbapenem resistance is limited. Therefore, in this study we determined the prevalence of carbapenemase among multidrug resistant gram negative enterobacteriaceae isolated from clinical specimens in a tertiary hospital.

Methods. The prevalence of carbapenems resistant isolates from 7 ICUs derived from hospital information systems.

Results. Prevalence results were highest in surgical intensive care units (general surgery, neurosurgery, cardiosurgery and urology) compared with paediatric, medical and neurology intensive care units. The most frequently reported carbapenems resistant microorganisms were Klebsiella spp. and Enterobacter spp.

Conclusion. This study describes the current epidemiology of CRE from the ICU at the UHC in Zagreb and highlights the importance of prevention strategies.

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