Aim. To present a case report.

A newborn child from a healthy mother was admitted to the neonatal intensive care unit in CHC Split exhibiting clinical symptoms of infection nine hours after birth.

Method. We used molecular tests to confirm suspected CMV infection. Polymerase chain reaction (PCR) is a widely available rapid and sensitive method of CMV detection based on the amplification of nucleic acids. PCR for CMV DNA can be either qualitative or quantitative, in which the amount of viral DNA in the respective sample is measured.

Results. Molecular testing on CMV using polymerase chain reaction (PCR) revealed the following: CMV detected in blood and urine sample.

Conclusion. Cytomegalovirus (CMV) is an important cause of congenital infection, which can result in neonatal deaths or contribute to deaths later in childhood. The human cytomegalovirus (CMV) is universally distributed among human populations as one of the most common cause of congenital infection with an incidence of about 0.15-2.0% in developed countries.

Despite these alarming facts, the general public healthcare system is often not aware of CMV and not enough is done to prevent congenital CMV infection. The molecular method of cytomegalovirus (CMV) isolation from urine or saliva is not a feasible routine technique for all newborns, and laboratory diagnosis of this infection would be useful both for epidemiological purposes and to identify and correct late sequelae. Extraction and amplification of viral DNA from dried blood spots (DBS) collected from babies in their first days of life during routine screening for genetic and metabolic disorders maybe useful for the early diagnosis of viral congenital infections.

Clinical Hospital Centre Split, Neonatal Intensive Care Unit, Split
University Hospital Centre Zagreb, Department of Clinical and Molecular Microbiology, Zagreb
Corresponding author: Zrinka Bošnjak,

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