Surfactant replacement therapy is the mainstay treatment for preterm infants with respiratory distress syndrome. In recent years, the growing interest in non-invasive ventilation has led to a variety of novel approaches of surfactant administration (intra-amniotic instillation, pharyngeal instillation, administration via laryngeal mask airway, administration via thin endotracheal catheter without IPPV, aerosolized/nebulized surfactant administration in spontaneously breathing infants). In our Centre last year a number of preterm infants with RDS were treated using MIST technique, in which surfactant is administered using a thin feeding tube inserted below the vocal cords. In the paper we describe our experience with the novel technique and report short term outcomes.
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