Article Data

  • Views 1564
  • Dowloads 158

Original Research

Open Access

Does magnesium sulfate affect the incidence of respiratory complications in children undergoing esophageal dilatation? An observational pilot study

  • MELTEM SAVRAN-KARADENIZ11
  • BAHADIR HAKAN OGUZ1
  • MUKADDER ORHAN-SUNGUR1
  • BASAK ERGINEL2
  • FERYAL GUN-SOYSAL2
  • MEHMET TUGRUL1
  • TULAY OZKAN-SEYHAN1

1 Department of Anesthesiology, Istanbul Faculty of Medicine, Istanbul University

2 Department of Pediatric Surgery, Istanbul Faculty of Medicine, Istanbul University

DOI: 10.22514/SV121.102016.15 Vol.12,Issue S1,October 2016 pp.91-95

Published: 10 October 2016

*Corresponding Author(s): MELTEM SAVRAN-KARADENIZ1 E-mail: mskaradeniz@gmail.com

Abstract

Background. In this pilot observational study, we aimed to investigate the effect of preoperative magnesium infusion on laryngospasm frequency and other res-piratory complications in children with respiratory findings undergoing esopha-geal dilatation after the ingestion of caustic substances.

Methods. Sixty children between the ages of 2 and 12 scheduled for esophageal dilatation were divided into two groups: the magnesium group (Group M), which consisted of children with respiratory symptoms and who received IV 30 mg/kg magnesium sulfate preoperatively, and the control group (Group C), who received the same volume of saline. Anesthesia was induced with fentanyl, propofol, and miva-curium and maintained using a 60% N2O and 2-3% sevoflurane mixture in oxygen. Demographic and hemodynamic data, as well as the incidence of respiratory com-plications (laryngospasm, bronchospasm, apnea, cough, and desaturation) during the perioperative period were recorded until the time of discharge from the recov-ery room.

Results. Demographic data and hemody-namics were similar in the two groups. The laryngospasm, bronchospasm, apnea, and cough incidences were also similar between the groups, although the desatu-ration incidence was lower in Group M than in Group C (p=0.013). The number of complications in total was lower in Group M as well (p=0.008), although the number of children who experienced complica-tions in each group was similar.

Conclusion. Prophylactic administration of 30 mg/kg of magnesium to children with respiratory symptoms may decrease the frequency of postoperative respiratory complications in children undergoing es-ophageal dilatation.

Keywords

corrosive stricture, magnesium sulfate, general anesthesia, complication, respiratory tract

Cite and Share

MELTEM SAVRAN-KARADENIZ1,BAHADIR HAKAN OGUZ,MUKADDER ORHAN-SUNGUR,BASAK ERGINEL,FERYAL GUN-SOYSAL,MEHMET TUGRUL,TULAY OZKAN-SEYHAN. Does magnesium sulfate affect the incidence of respiratory complications in children undergoing esophageal dilatation? An observational pilot study. Signa Vitae. 2016. 12(S1);91-95.

References

1. Riffat F, Cheng A. Pediatric caustic ingestion: 50 consecutive cases and a review of the literature. Dis Esophagus 2009;22:89–94.

2. Contini S, Scarpignato C. Caustic injury of the upper gastrointestinal tract: a comprehensive review. World J Gastroenterol 2013;19:3918–30.

3. Baskin D, Urganci N, Abbasoğlu L, Alkim C, Yalçin M, Karadağ C, et al. A standardised protocol for the acute management of cor-rosive ingestion in children. Pediatr Surg Int 2004;20:824–8.

4. Gün F, Abbasoğlu L, Celik A, Salman ET. Early and late term management in caustic ingestion in children: a 16-year experience. Acta Chir Belg 2007;107:49–52.

5. Alalami AA, Ayoub CM, Baraka AS. Laryngospasm: review of different prevention and treatment modalities. Paediatr Anaesth 2008;18:281–8.

6. Shan Z, Rong Y, Yang W, Wang D, Yao P, Xie J, et al. Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis. Respir Med 2013;107:321–30.

7. Gulhas N, Durmus M, Demirbilek S, Togal T, Ozturk W, Ersoy MO. The use of magnesium to prevent laryngospasm after tonsillec-tomy and adenoidectomy: a preliminary study. Paediatr Anaesth 2003;13:43–7.

8. Kovesi T, Rubin S. Long-term complications of congenital esophageal atresia and/or tracheoesophageal fistula. Chest 2004;126:915–25.

9. Harding SM, Allen JE, Blumin JH, Warner EA, Pellegrini CA, Chan WW. Respiratory manifestations of gastroesophageal reflux disease. Ann N Y Acad Sci 2013;1300:43–52.

10. Becke K. Anesthesia in children with a cold. Curr Opin Anaesthesiol 2012;25:333–9.

11. Bordet F, Allaouchiche B, Lansiaux S, Combet S, Pouyau A, Taylor P, et al. Risk factors for airway complications during general an-aesthesia in paediatric patients. Paediatr Anaesth 2002;12:762–9.

12. Hampson-Evans D, Morgan P, Farrar M. Pediatric laryngospasm. Paediatr Anaesth 2008;18:303–7.

13. Al-alami A, Markakis M, Shehata A, Zestos MM, Baraka AS. Pediatric laryngospasm: prevention and treatment. Curr Opin Anaes-thesiol 2009;22:388–95.

14. Olsson GL, Hallen B. Laryngospasm during anaesthesia. A computer-aided incidence study in 136,929 patients. Acta Anaesthesiol Scand 1984;28:567–75.

15. Bauman NM, Sandler AD, Schmidt C, Maher JW, Smith RJ. Reflex laryngospasm induced by stimulation of distal esophageal affer-ents. Laryngoscope 1994;104:209–14.

16. Cheuk DKL, Chau TCH, Lee SL. A meta-analysis on intravenous magnesium sulphate for treating acute asthma. Arch Dis Child 2005;90:74–7.

17. Sydow M, Crozier TA, Zielmann S, Radke J, Burchardi H. High-dose intravenous magnesium sulfate in the management of life-threatening status asthmaticus. Intensive Care Med 1993;19:467–71.

18. Seyhan TO, Tugrul M, Sungur MO, Kayacan S, Telci L, Pembeci K, et al. Effects of three different dose regimes of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynacological surgery. Br J Anaesth 2006;96:247–52.

19. Saharan S, Lodha R, Kabra SK. Management of status asthmaticus in children. Indian J Pediatr 2010;77:1417–23.

20. Scarfone RJ, Loiselle JM, Joffe MD, Mull CC, Stiller S, Thompson K, et al. A randomized trial of magnesium in the emergency depart-ment treatment of children with asthma. Ann Emerg Med 2000;36:572–8.

21. Hodgson RE, Rout CC, Rocke DA, Louw NJ. Mivacurium for caesarean section in hypertensive parturients receiving magnesium sulphate therapy. Int J Obstet Anesth 1998;7:12–7.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top