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Original Research

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Effects of a percutaneous coronary intervention or conservative treatment strategy on treatment outcomes in elderly female patients with acute coronary syndrome

  • DOMAGOJ MARKOVIC1
  • ANDRO RADANOVIC2
  • ANTE MIHOVILOVIC3
  • JOSKO BOZIC4
  • AJVOR LUKIN2
  • MIROSLAV SIMUNIC5

1Clinic for heart and cardiovascular diseases, University Hospital of Split, Split, Croatia

2 Dalmatian County Institute of Emergency Medicine, Croatia

3 Department of Maxillofacial Surgery, University Hospital of Split, Split, Croatia

4 Department of Pathophysiology, School of Medicine, University of Split, Split, Croatia

5 Department of Internal Medicine, University Hospital of Split, Split, Croatia

DOI: 10.22514/SV121.102016.16 Vol.12,Issue S1,October 2016 pp.96-100

Published: 10 October 2016

*Corresponding Author(s): DOMAGOJ MARKOVIC E-mail: markovic.domagoj@gmail.com

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Abstract

Aim. To determine the difference in hospi-tal outcomes between percutaneous coro-nary intervention (PCI) and conservative treatment of elderly female patients hos-pitalized for acute coronary syndrome (ACS).

Material and Methods. This controlled study included 123 female patients admit-ted to the Clinic for heart and cardiovas-cular diseases University Hospital of Split with a diagnosis of ACS and multiple car-diovascular risk factors. We recorded their habits, history, demographics, presenting symptoms, electrocardiograms, ultra-sound results, laboratory tests, diagnostic tests and treatment. We compared these data between the two groups, i.e., those treated with conservative therapy and those treated with PCI.

Results. There were fewer arrhythmias (P<0.001) and episodes of heart failure (P<0.001) during hospitalization in the PCI group than in the conservative ther-apy group. There was no significant differ-ence in complications between the groups (P=0.887).

Conclusion. Elderly female patients with ACS treated with PCI had less arrhythmias and heart failure during hospitalization than those treated with conservative ther-apy and there was no difference in com-plications. These results suggest that even high risk patients have better outcomes af-ter treatment with PCI, and therefore PCI is suggested as first-line treatment in these patients, regardless of risk factors.

Keywords

percutaneous coronary interven-tion, acute coronary syndrome, women

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DOMAGOJ MARKOVIC,ANDRO RADANOVIC,ANTE MIHOVILOVIC,JOSKO BOZIC,AJVOR LUKIN,MIROSLAV SIMUNIC. Effects of a percutaneous coronary intervention or conservative treatment strategy on treatment outcomes in elderly female patients with acute coronary syndrome. Signa Vitae. 2016. 12(S1);96-100.

URL:

https://www.signavitae.com/articles/10.22514/SV121.102016.16

References

1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997 May 24; 349(9064):1498–504.

2. untitled – guidelines-nste-acs-ft.pdf [Internet]. [Cited 2014 Jun 26]. Available from: http://www.escardio.org/guidelines-surveys/esc-guidelines/guidelinesdocuments/guidelines-nste-acs-ft.pdf

3. American Heart Association. Heart Disease and Stroke Statistics– 2004 Update. Dallas, TX: American Heart Association, 2003.

4. Ayanian JZ, Epstein AM. Differences in the use of procedures between women and men hospitalized for coronary heart disease. N Engl J Med 1991 Jul 25;325(4):221–5.

5. Healy B. The Yentl syndrome. N Engl J Med 1991 Jul 25;325(4):274–6.

6. Poon S, Goodman SG, Yan RT, Bugiardini R, Bierman AS, Eagle KA, et al. Bridging the gender gap: Insights from a contemporary analysis of sex-related differences in the treatment and outcomes of patients with acute coronary syndromes. Am Heart J 2012 Jan;163(1):66–73.

7. Blomkalns AL, Chen AY, Hochman JS, Peterson ED, Trynosky K, Diercks DB, et al, CRUSADE Investigators. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol 2005 Mar 15;45(6):832–7.

8. Radovanovic D, Erne P, Urban P, Bertel O, Rickli H, Gaspoz J-M. Gender differences in management and outcomes in patients with acute coronary syndromes: results on 20 290 patients from the AMIS Plus Registry. Heart 2007 Nov;93(11):1369–75.

9. Jneid H, Fonarow GC, Cannon CP, Hernandez AF, Palacios IF, Maree AO, et al, Get With the Guidelines Steering Committee and In-vestigators. Sex differences in medical care and early death after acute myocardial infarction. Circulation 2008 Dec 16;118(25):2803–10.

10. El-Menyar A, Zubaid M, Sulaiman K, AlMahmeed W, Singh R, Alsheikh-Ali AA, Al Suwaidi J. Atypical presentation of acute coro-nary syndrome: A significant independent predictor of in-hospital mortality. J Cardiol 2011 Mar;57(2):165–71.

11. Xhyheri B, Bugiardini R. Diagnosis and treatment of heart disease: are women different from men? Prog Cardiovasc Dis 2010 Dec;53(3):227–36.

12. Bugiardini R, Bairey Merz CN. Angina with “normal” coronary arteries: a changing philosophy. JAMA J Am Med Assoc 2005 Jan 26;293(4):477–84.

13. Rittger H, Schnupp S, Sinha A-M, Breithardt O-A, Schmidt M, Zimmermann S, et al. Predictors of treatment in acute coronary syn-dromes in the elderly: impact on decision making and clinical outcome after interventional versus conservative treatment. Catheter Cardiovasc Interv Off J Soc Card Angiogr Interv 2012 Nov 1; 80(5):735–43.

14. Wallentin L, Lagerqvist B, Husted S, Kontny F, Ståhle E, Swahn E. Outcome at 1 year after an invasive compared with a non-invasive strategy in unstable coronary-artery disease: the FRISC II invasive randomised trial. FRISC II Investigators. Fast Revascularisation during Instability in Coronary artery disease. Lancet 2000 Jul 1;356(9223):9–16.

15. Lagerqvist B, Husted S, Kontny F, Ståhle E, Swahn E, Wallentin L. 5-year outcomes in the FRISC-II randomised trial of an invasive versus a non-invasive strategy in non-ST-elevation acute coronary syndrome: a follow-up study. Lancet 2006 Sep 22;368(9540):998–1004.

16. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes – guidelines-NSTE-ACS-FT-2007.pdf [Internet]. [Cited 2014 Jun 26]. Available from: http://www.escardio.org/guidelines-surveys/esc-guidelines/Docu-ments/ACS/guidelines-NSTE-ACS-FT-2007.pdf

17. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al, STRAW + 10 Collaborative Group. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 2012 Apr;97(4):1159–68.

18. Killip III T, Kimball JT. Treatment of myocardial infarction in a coronary care unit: A Two year experience with 250 patients. Am J Cardiol 1967 Oct;20(4):457–64.

19. The Criteria Committee of the New York Heart Association Nomenclature and criteria for diagnosis of diseases of the heart and blood vessels. Boston: Little Brown, 1964.

20. Paraschos A, Callwood D, Wightman MB, Tcheng JE, Phillips HR, Stiles GL, et al. Outcomes following elective percutaneous coro-nary intervention without on-site surgical backup in a community hospital. Am J Cardiol 2005 May 1;95(9):1091–3.

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