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Case Report

Open Access

Transfusion Related Acute Lung Injury: A severe case triggered with anti-HLA class II antibodies in the recipient

  • HALE BORAZAN1
  • SEBNEM YOSUNKAYA2
  • ALPER YOSUNKAYA1

1,Department of Anesthesiology and Reanimation Selcuk University Meram Medical Faculty

2,Department of Pulmonary Medicine Selcuk University Meram Medical Faculty

DOI: 10.22514/SV71.042012.11 Vol.7,Issue 1,April 2012 pp.52-56

Published: 30 April 2012

*Corresponding Author(s): HALE BORAZAN E-mail: borazanh@hotmail.com

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Abstract

Transfusion-related acute lung injury (TRALI) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. The classic TRALI syndrome is characterized by the suddenly onset of respiratory failure within 2-6 hrs of the transfusion of a blood product, generally transient, resolves within 48-96 hrs spontaneously, and has a better prognosis. Nonetheless there is an expanded definition of TRALI syndrome up to 72 hrs, which is called delayed TRALI. The potential causes of TRALI can be explained by two distinct mechanism including the anti-leukocyte antibodies in donor plasma or in recipient plasma with the reverse mechanism, and biological response modifiers in susceptible individuals. This report highlights the succesful management of a classic TRALI case that was seen approximately two hours after the transfusion of a packed red blood cell and triggered with anti-HLA class II antibodies in the recipient with reverse mechanism accompanied by neutropenia together.

Keywords

transfusion, acute lung injury, transfusion related acute lung injury, anti HLA antibodies

Cite and Share

HALE BORAZAN,SEBNEM YOSUNKAYA,ALPER YOSUNKAYA. Transfusion Related Acute Lung Injury: A severe case triggered with anti-HLA class II antibodies in the recipient. Signa Vitae. 2012. 7(1);52-56.

URL:

https://www.signavitae.com/articles/10.22514/SV71.042012.11

References

1. Kopko PM, Holland PV. Transfusion-related acute lung injury. Br J Haematol 1999;105:322-9.

2. Kopko PM, Marshall CS, MacKenzie MR, Holland PV, Popovsky MA. Transfusion-related acute lung injury: report of a clinical look-back investigation. JAMA 2002;287:1968-71.

3. Marik PE, Corwin HL. Acute lung injury following blood transfusion: Expanding the definition. Crit Care Med 2008;36:3080-84.

4. Toy P, Popovsky MA, Abraham E, Ambrusso DR, Holnes LG, Kopko PM, et al. The National Heart Lung and Blood Institute Working Group on TRALI. Transfusion-related acute lung injury: Definition and review. Crit Care Med 2005;33:721-6.

5. Kleinman S, Caulfield T, Chan P, Davenport R, McFarland J, McPhedran S, et al. Toward on understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 2004;44:1774-89.

6. Bux J. Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion. Vox Sang 2005;89(1):1-10.

7. Sachs UJ, Kauschat D, Bein G. White blood cell-reactive antibodies are undetectable in solvent/detergent plasma. Transfusion. 2005;45(10):1628-31.

8. Gajic O, Rana R, Winters JL, Y􀀁lmaz M, Mendez JL, Rickman OB, et al. Transfusion related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med 2007;176:886-91.

9. Wallis J. Transfusion-related acute lung injury (TRALI)— under-diagnosed and under-reported. Br J Anaesth 2003;90:573-6.

10. Jawa RS, Anillo S, Kulaylat MN. Transfusion-related acute lung injury. J Intensive Care Med 2008;23:109-21.

11. Holnes L, Knippen MA, Simmons L, Lachenbruch PA. Fatalities caused by TRALI. Transfus Med Rev 2004;18:184-8.

12. Nishimura M, Hashimoto S, Takanashi M, Okazaki H, Satake M, Nakajima K. Role of anti-human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related acute lung injury. Transfus Med 2007;17:129-34.

13. Cherry T, Steciuk M, Reddy VVB, Marques MB. Transfusion-Related Acute Lung Injury. Am J Clin Pathol 2008;129:287-97.

14. Benson AB, Mors M, Silliman CC. Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill. Br J Haematol 2009;147:431-43.

15. Webert KE, Blajchman MA. Transfusion-related acute lung injury. Curr Opin Hematol 2005;12:480–7.

16. Zhou L, Giacherio D, Cooling L, Davenport RD. Use of B-natriuretic peptide as a diagnostic marker in the differential diagnosis of transfu-sion-associated circulatory overload. Transfusion. 2005;45:1056-63.

17. Silliman CC, McLaughlin NJ. Transfusion-related acute lung injury. Blood Reviews 2006;20:139–59.

18. Nakagawa M, Toy P. Acute and transient decrease in neutrophil count in transfusion-related acute lung injury: cases at one hospital. Transfusion 2004;44:1689-94.

19. Kalhan R, Mikkelsen M, Dedhiya P, Christie J, Gaughan C, Lanken PN, et al. Underuse of lung protective ventilation: analysis of potential factors to explain physician behavior. Crit Care Med 2006;34:300-6.

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