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Invasive Candida infections in the nursery: state of the art

  • PAOLO MANZONI1
  • ELIO CASTAGNOLA2
  • EVELYNE JACQZ-AIGRAIN3
  • MICHAEL MOSTERT4
  • MAURO STRONATI5
  • DANIELE FARINA1

1Neonatology and NICU, S. Anna Hospital

2Infectious Diseases Unit, “G. Gaslini” Children’s Hospital

3Department of Paediatric Pharmacology and Pharmacogenetics, Clinical Investigation Centre Inserm CIC 9202 Hospital “Robert Debré”

4,Department of Paediatrics University of Torino

5Neonatology, IRCCS S

DOI: 10.22514/SV92.112014.1 Vol.9,Issue 2,November 2014 pp.5-8

Published: 03 November 2014

*Corresponding Author(s): PAOLO MANZONI E-mail: paolomanzoni@hotmail.com

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Abstract

Neonatal sepsis caused by fungi (mainly Candida spp.) causes a huge burden of morbidity and mortality, poor late outco-mes, as well as increased hospital costs. 

Invasive Candida Infections (ICI) include bloodstream, urine, cerebrospinal, peritoneal infections, infections starting from burns and wounds, or from any other usually sterile site.

Premature neonates are particularly prone to this kind of disease, due to their decreased innate and adaptive immunities, translating into a specific, decreased resistance to candidiasis.

This specific, increased risk for ICI is greatest when gestational age and birth weight are lowest. As the burden of ICI has been increasing over the last years, research efforts have been focused towards identifying key risk factors, effective pre-ventative strategies, and efficacious and well-tolerated antifungal drugs for the neonatal population.

This article summarizes the most remarkable issues in these areas, and features an overview of the current diagnostic, preventative and treatment strategies.

Keywords

Candida, neonate, infecti-on, preterm, micafungin, fluconazole

Cite and Share

PAOLO MANZONI,ELIO CASTAGNOLA,EVELYNE JACQZ-AIGRAIN,MICHAEL MOSTERT,MAURO STRONATI,DANIELE FARINA. Invasive Candida infections in the nursery: state of the art. Signa Vitae. 2014. 9(2);5-8.

URL:

https://www.signavitae.com/articles/10.22514/SV92.112014.1

References

1. Kaufman D, Fairchild KD. Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 2004;17:638–80.

2. Saiman L, Ludington E, Pfaller M, Rangel-Frausto S, Wiblin T, Dawson J, et al. Risk factors for candidemia in neonatal intensive care unit patients. Pediatr Infect Dis J 2000;19:319–24.

3. Manzoni P, Stronati M, Jacqz-Aigrain E, Maragliano R, Ruffinazzi G, Rizzollo S, et al. Correct choices for correct treatments: key issues in the management of Candida infections in preterm neonates. Early Hum Dev 2012; Suppl 2: 98-100.

4. Benjamin DK Jr, Stoll BJ, Gantz MG, Walsh MC, Sanchez PJ, Das A, et al. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics 2010;126:e865–73.

5. Kaufman D. Strategies for prevention of neonatal invasive candidiasis. Semin Perinatol 2003;27:414–24.

6. David A. Kaufman, Paolo Manzoni. Strategies to Prevent Invasive Candidal Infection in Extremely Preterm Infants. Clin Perinatol 2010;37:611–28.

7. Benjamin DK Jr, Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics 2006;117:84–92.

8. Picone S, Manzoni P, Bedetta M, Mostert M, Benjamin DK Jr, Paolillo P. Pharmacological resolution of a multiloculated Candida spp. liver abscess in a preterm neonate. Early Hum Dev 2013;89 Suppl 1:47–50.

9. Manzoni P, Rinaldi M, Cattani S, Pugni L, Romeo MG, Messner H, et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low birth weight neonates: a randomized trial. JAMA 2009;302(13):1421–8.

10. Manzoni P, Meyer M, Stolfi I. Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial. Early Hum Dev 2014;90 Suppl 1:45–50.

11. Karlowicz MG, Hashimoto LN, Kelly RE Jr, Buescher ES. Should central venous catheters be removed as soon as candidemia is detected in neonates? Pediatrics 2000;106:E63.

12. Hsieh E, Smith PB, Jacqz-Aigrain E, Kaguelidou F, Cohen-Wolkowiez M, Manzoni P, et al. Neonatal fungal infections: when to treat? Early Hum Dev 2012;2:6-10.

13. Cordonnier C, Pautas C, Maury S, Vekhoff A, Farhat H, Suarez F, et al. Empirical versus preemptive antifungal therapy for high-risk, febrile, neutropenic patients: a randomized, controlled trial. Clin Infect Dis 2009;38:1042–51.

14. Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of Candidabloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother 2005;49:3640–5.

15. Benjamin DK Jr, DeLong ER, Steiback WJ, Cotton CM, Walsh TJ, Clark RH. Empirical therapy for neonatal candidemia in very low birth weight infants. Pediatrics 2003;112:543–50.

16. Castagnola E, Jacqz-Aigrain E, Kaguelidou F, Maragliano R, Stronati M, Rizzollo S, et al. Fluconazole use and safety in the nursery. Early Hum Dev 2012;2:11-5.

17. Manzoni P, Galletto P, Rizzollo S. Liposomal amphotericin B does not induce nephrotoxicity or renal function impairment in premature neonates. Early Hum Dev 2012;88 Supll 2:86–91.

18. Queiroz-Telles F, Berezin E, Leverger G, Freire A, van der Vyver A, Chotpitayasunondh T, et al. Micafungin Invasive Candidiasis Study Group. Micafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: substudy of a randomized doubleblind trial. Pediatr Infect Dis J 2008;27:820–6.

19. Zhao W, Hope WW, Manzoni P, Jacqz-Aigrain E. Optimizing Micafungin Dosing in Children. Ped Infect Dis J 2012;11:1211-2.

20. Paolo Manzoni, Chunzhang Wu, Lorraine Tweddle, Emmanuel Roilides. Micafungin in Premature and Non-premature Infants: A Systematic Review of 9 Clinical Trials. PIDJ 2014, in press.

21. Manzoni P, Benjamin DK Jr, Hope W, Rizzollo S, Del Sordo P, Stronati M, et al. The management of Candida infections in preterm neonates and the role of micafungin. J Matern Fetal Neonatal Med 2011; 24 Suppl 2: 24-7.

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