General information

Manuscripts sent to SIGNA VITAE should conform with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals (

SIGNA VITAE publishes papers covering adult, pediatric and neonatal intensive care, as well as anesthesiology and emergency medicine. SIGNA VITAE will consider for publication:

  • Review articles
  • Original articles
  • Short reports
  • Letters to the editor

Case reports will be considered only in exceptional circumstances and if they cover an outstanding medical condition or achievement in treating such a condition.

Editorial commentaries, book reviews, and notices of meetings are also published occasionally.

Short reports and Case reports should contain up to 1000 words, 10 references and 1 to 2 tables or figures. Letters to the editor that discuss a recent SIGNA VITAE article should contain up to 500 words and 5 references.

Preparation and submission of the manuscript

Manuscripts should be written in English. American or British English can be used but should be applied consistently throughout the article. Prior to submission, manuscripts should preferably be edited by native English speakers.

It is recommended that the langugage level used in the manuscript is B2 (or higher) of the Common European Framework of Reference for Languages (CEFR).

NOTICE: Since January 12th, we started using the new version of the SignaTrack application. All old users will need to reset their passwords and update their personal information on the profile page.

Submit your manuscript using SignaTrack App, that will guide you throughout the process.

In order to complete the submission process, upload of the following sections to the SignaTrack WebApp will be requested:

  • Title of the paper
  • Authorship information
  • Summary page (abstract and MeSH key words)
  • Text pages (main text of the article, references, tables and figures)
  • Supplementary materials (optional)
  • Statement to the Editor-in-Chief

Authorship information should include a) the authors’ names, e-mails, highest academic degrees and institutional affiliations, and b) the name, e-mail, highest academic degree, telephone number, and ORCID ID of the corresponding author.

Summary page should contain Abstract and MeSH key words. The Abstract in structured form, not exceeding 250 words, should end with one or two concluding sentences, summarizing the significance of the article. Three to ten key words, taken from Medical Subject Headings of Index Medicus, should be written in input fields after the Abstract .

Text pages of the manuscript should be organized under the following sections: Introduction, Materials and Methods, Results, Discussion. References, Acknowledgments, and Tables and Figures. Each Table and Figure, together with its appropriate Legend, should be printed on a separate page.

Supplementary materials. This section is optional and may be used to provide more detailed information in the form of raw data, multimedia objects such as video or audio clips, or any table or figure considered too lengthy for the printed version of the article.

Statement to the Editor-in-Chief. Manuscripts submitted for publication should be accompanied by a letter to the Editor-in-Chief, signed by all authors. The letter should contain the statement that the manuscript has not been submitted for publication elsewhere, and that the authors have contributed significantly in executing the study and/or preparing the manuscript. If the article is accepted for publication, a Conflict-of-Interest Statement will be requested.

Statement of Human Rights. Manuscripts describing human research must contain the statement that the study was approved by the relevant Institutional Review Board (IRB). The IRB approval of the study protocol, as well as consent procedures required by the IRB, should appear at the beginning of the Methods’ section. The research should be in accordance with the Helsinki Declaration of 1975, as revised in 2010.

Statement of Informed Consent. Patients’ names, initials, hospital numbers or photographs should be omitted, unless they are considered essential. The patient (or parent or guardian) should give written informed consent for publishing any personal material.

Conflict-of-Interest Statement. At the time of submitting a manuscript each author is required to write a statement of potential financial disclosure related to him or herself. The disclosure pertains to financial relationships with manufacturers that have an interest in the subject matter of their manuscript. Conflict of interest refers to both personal fees received from manufacturers and funds donated to the authors’ departments.

Statistical Methods. List the tests used and relate them to specific data analysis. For parametric methods, normality, shape of distribution and appropriate sample or number of cases in each group must be tested, for example in t-test or ANOVA analysis. Nonparametric methods should be used to compare groups with small number of cases and when the distribution of the dependent variable is not normal. Exact methods should be used as extensively as possible in the analysis of categorical data.

Results should be presented with only as much precision as is of scientific value. Descriptive statistics such as measures of central tendency may be presented with only one decimal place but standard deviations with two decimal places. Measures of association, such as odds ratios and other statistical values such as t-value or F-value should ordinarily be reported to two decimal places whereas P value must be presented with three decimal places. P values smaller than 0.001 should be reported as P<0.001. Each table and figure should be put on a separate sheet of paper. Each table in the paper should be self-explanatory, with an adequate title, legend, and logical presentation of data. Please, do not present the same data in more than one way: present them in a table OR a figure.

The references should be numbered consecutively in the order they first appear in the text. They should be identified by Arabic numerals in parentheses in the text, tables and legends. Titles of journals should be abbreviated according to the International List of Periodical Title World Abbreviations used by the Index Medicus, and references should be given according to the Vancouver declaration.

Sample References:

Journal articles

Sprung J, Flick RP, Gleich SJ, Weingarten TN. Perioperative cardiac arrests. Signa vitae 2008;3:8-12.

In Press

van Saene HKF, Kalenic, S, Peric, M. The Addition of enteral to parenteral antimicrobials may Prolong the antibiotic era. Signa vitae. (in press)


Lang TA, Secic M. How to report statistics in medicine. Philadelphia: American College of Physicians; 1997.

Articles in Books

Kolacek S, Mestrovic J. Vascular access, including complications. In: Langnas AN, Goulet O, Quigley EMM, Tappenden KA, editors. Intestinal failure, 1st ed. Malden, MA: Blackwell Publishing; 2008. p. 142-150.

Journal Article in Electronic Format

Strahovnik I, Podbregar M. Measurement of skeletal muscle tissue oxygenation in the critically ill. Signa Vitae (serial online) 2008 April (cited 2009 January 8); vol3. Available from:

Anti-Plagiarism Check

After the submission, your manuscript will be electronically screened for plagiarism. If plagiarism (self-plagiarism included) is detected, manuscript will be immediately rejected.

Peer Review

All articles submitted to SIGNA VITAE are reviewed by the Editorial Board immediately after the Anti-Plagiarism Check. Articles that do not meet the standards of the journal will be declined without further review, while the remaining articles will usually be sent to two external experts in the field. The decision of the external reviewers can be expected within 5 weeks of submission. Authors are not given the names of the reviewers of their article. Editorial Board members and reviewers need to declare any conflict of interest they may have in reviewing a manuscript. The Editors make the final decision on the manuscript. Authors who have any objection to the decision of the Editors are welcome to approach the Editorial Board with their appeal.

Specialist statistical reviewers are involved whenever the content of the manuscript requires their collaboration.