Volume 5 Supplement 1

Critical (Intensive) Care Medicine and CPR - A Personal History By Max Harry Weil (Views : 2964 times)


I perceive that the most consitent pursuits of successful innovators and leaders in medicine, as in all endeavors, come from aspirations generated by dreams rather than hope or by fate alone; from the excitement with which the dreamer atracts collaborators who have prepared minds and skillful hands; they join talents and destinities to convert the dream to expert plans.Contigent on the vigor, the persistence and on the attention to detail with which they commit to the execution of their plans, the secure the advances that contribute to the social goods and bring ultimate success to all who have jioned destinies to seriously pursue those dreams.

Key words: cardiopulmonary resuscitation, critical care medicine, intensive care medicine, history, progress, future


From Science to Guidelines: The Future for Resuscitation (Views : 3761 times)


The periodic development and publication of treatment guidelines is integral to the field of cardiopulmonary resuscitation and emergency cardiovascular care. The methods for guideline development have evolved over the past few decades, and the process itself has become the subject of increasing scientific investigation. An internationally validated tool for assessing the quality of clinical practice guidelines is The Appraisal of Guidelines for Research and Evaluation (AGREE) instrument. Applying this tool to the ILCOR 2010 International Consensus on CPR (cardiopulmonary resuscitation) and ECC (emergency cardiac care) Science with Treatment Recommendations (CoSTR) and the resulting member council guidelines will be a valuable initial step in evaluating both the process and the product. By doing so, important strengths can be recognized as well as opportunities for improvement moving forward. Beyond validated tools to assess and improve the quality of the traditional guidelines process, a critical reassessment of the overall strategy for improving cardiac arrest outcomes is indicated. From the lay-provider perspective, innovative approaches to facilitate performance of bystander CPR are needed. This is likely to entail more individualized instructional methods that are titrated to the provider's capabilities for learning and performance. What the future might hold for professional providers is a more individualized treatment strategy titrated to real-time physiologic monitoring with mechanized delivery of therapies guided by real-time computer-aided medical decision-making. These individualized instructional and treatment strategies could revolutionize our approach to cardiac arrest resuscitation, and dramatically change how guidelines are developed, implemented and evaluated.

Keywords: cardiac arrest, cardiopulmonary resuscitation, CPR, guidelines


Hypothermia during percutaneous coronary intervention in comatose survivors of cardiac arrest (Views : 3694 times)


Urgent invasive coronary strategy including coronary angiography and percutaneous coronary intervention (PCI) is feasible and safe in combination with mild induced hypothermia and may significantly improve survival with good neurological outcome in comatose patients after reestablishment of spontaneous circulation (ROSC). The starting hypothermia already in the prehospital setting or immediately after arrival to the catheterization laboratory to complement urgent coronary angiography and PCI seems to be a logical strategy.

Keywords: cardiac arrest, urgent coronary angiography, percutaneous coronary intervention PCI , mild induced hypothermia, outcome


Targeting the Endothelium (Views : 2814 times)


The endothelium is an active organ with paracrine-endocrine capabilities that directs a multitude of physiological actions both locally and remotely. Cardiac arrest and resuscitation is a model of whole body ischemia reperfusion injury, interventions that have their basis in cytoprotection, reduction of the inflammatory cascade, fibrinolysis and improvement of microvasculature blood flow target the endothelium. This presentation will review pharmacologic, cell targeted therapies and periodic acceleration (pGz) interventions that have the endothelium in part as the target organ. The clinical potential of such interventions as preconditioning, conditioning and postconditioning strategies associated with cardiac arrest will be defined.

Keywords: endothelium, periodic acceleration (pGz), cardiac arrest, cardiopulmonary resuscitation, ischemia reperfusion, nitric oxide, shear stress


Sex Hormones and Gender Effects following Trauma-Hemorrhage (Views : 3122 times)


Trauma is the leading cause of death in the industrialized world between the ages of one and 40. A number of risk factors including age and gender have been implicated in this regard. It is therefore not surprising that the majority of trauma victims are young males. Their mortality rate following trauma is not only higher compared to females, but they are also more prone to subsequent sepsis. Age and gender are therefore important factors in the prevalence of traumatic injury as well as in susceptibility to subsequent septic complications.

Key words: trauma, mortality, age, gender, sex hormones, sepsis, cardiovascular/immunological alterations




Most Accessed Articles

Original Articles


Abstract Introduction. The contribution of tracheotomy in comparison to intubation in patients on the resuscitation ward ...

Clinical s

Abstract Elevated intraabdominal pressure (IAP) has been claimed to play a role in abdominal compartment syndrome. ...


Abstract Objectives. We examined the relationship between partial end-tidal CO2 (pet) and mean arterial pressure in ...

Case Reports

Severe barium sulphate aspiration: a report of two cases and review of the literature

Abstract Aspiration of barium sulphate is a well-recognized complication, occurring accidentally during examinations of the upper gastrointestinal system using contrast media. Rarely, large amounts of barium sulphate are inadvertently aspirated into ...

Pulmonary hypertension leading to right heart failure in a patient with IgA gammapathy

Abstract Amyloidosis is a rare disorder characterized by the deposition of amorphous, extracellular, insoluble fibrillar protein in various tissues of the body. Pulmonary hypertension usually occurs in the last stages of ...

Myotubular myopathy associated with hypoxic-ischemic encephalopathy as a cause of prolonged ventilat

Keywords: myotubular myopathy, muscle biopsy, genetic analysis hypoxic-ischemic ...

Review Articles

Venous oximetry

Abstract Tissue hypoxia is the central pathophysiological process in shock and an important co-factor in the development of organ dysfunction. Hemodynamic parameters, usually used to assess the perfusion of organs and ...

Pediatric Shock

Abstract Millions of children die of shock due to various etiologies each year. Shock is a state of circulatory dysfunction where the metabolic demands of the tissue cannot be met by ...

Inpatient management of alcohol withdrawal: a practical approach

Abstract Alcohol intake contributes directly or indirectly to 15 to 20% of medical problems in primary care or an inpatient setting. It is estimated that approximately 500,000 episodes of withdrawal will ...

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