In patients undergoing lung surgery mechanical ventilation and surgical trauma may induce alveolar and systemic inflammatory response. One-lung ventilation (OLV) has become as a standard procedure in thoracic surgery. It is also the main cause of acute inflammatory response and is associated with ALI and ARDS.
Demonstrating the influence of volatile anaesthetics on the inflammatory response and the treatment outcome in patients undergoing lung surgery with one lung ventilation (OLV) is still a great challenge.
The effects of sevoflurane on local release of inflammatory cytokines has been shown before. The added value of our study is that the systemic immunomodulatory effect of sevoflurane, postoperative clinical outcome and complications were tested.
The aim of the study was to prospectively investigate the systemic anti-inflammatory effect of the volatile anaesthetic sevoflurane in patients undergoing lung surgery with OLV.
Key words: one-lung ventilation, sevoflurane, inflammation