Impact factor 0.175

Signa Vitae

Journal of Intensive Care and Emergency Medicine

The treatment of posthaemorrhagic hydrocephalus

Abstract

The paper presents the authors’ analysis of their own treatments of intraventricular bleeding and posthaemorrhagic hydrocephalus in premature infants in the period from December 2009 to January 2016.

Infants who are born before the 37th week of pregnancy are at a higher risk for perinatal complications. Intraventricular bleeding is a common complication in premature infants with low birth weight who are treated in units for intensive care and therapy.

Infants who are most at risk are those with low birth weight (under 1,500 g) and born before the 30th week of gestation. According to data from literature, 30 – 50% of infants born before the 30th week suffer intraventricular haemorrhage. More severe haemorrhage results in posthaemorrhagic hydrocephalus.

High morbidity and mortality require an early recognition, treatment and regular follow-up of these infants.

Key words: premature infant, intraventricular bleeding, hydrocephalus, treatment

Read More

Prenatal and postnatal risk factors for developing bronchopulmonary dysplasia

Abstract

Aim. To determine prenatal and postnatal risk factors for developing bronchopulmonary dysplasia in infants < 30 weeks of gestational age.
Methods. Over a 22-month period, 115 newborns were enrolled in the study. Details including gestational age, sex, birth weight, prenatal steroids, surfactant treatment, ventilatory support, days of postnatal oxygen requirement, late onset sepsis/pneumonia, air leaks, patency of ductus arteriosus, and fluid intake were collected. The presence of chorioamnionitis was diagnosed by histological examination. Commercial ELISA kits were used for the determination of the IL-6 and IL-8 levels.
Results. Twenty-five infants developed BPD and 90 were enrolled in the non BPD group. Lower gestational age and male sex increased the risk for BPD. There was no difference in the presence of chorioamnitis and the level of IL-6 and IL-8 measured in cord blood and gastric aspirate between the groups. Intubation in the delivery room (resuscitation), need for surfactant treatment, mechanical ventilation, late onset sepsis/pneumonia, increased oxygenation index increased the risk for BPD after adjustment for GA and gender.
Conclusion. In our cohort of infants with GA < 30 weeks exposure to prenatal inflammation did not increase the risk for BPD. However, low gestational age, male sex, need for resuscitation, mechanical ventilation and late onset sepsis were major risk factors for BPD development.

Key words: premature infant, bronchopulmonary dysplasia, respiratory distress syndrome, chorioamnionitis, interleukin 6, interleukin 8

Read More

© 2019. Signa Vitae. Except where otherwise noted, content on this site is licensed under a Creative Commons Attribution 4.0 International license.