RT  - Signa Vitae
ID  - 10.22514/SV112.062016.12
T1  - Late onset perinatal sepsis in the neonatology intensive care unit – risk factors
A1  - HANA DOBRIĆ
A1  - VESNA MILAS
A1  - KREŠIMIR MILAS
K1  - low-birth-weight pre-term in-fants
K1  - nosocomial infections
K1  - risk factors
K1  - umbilical venous catheters
K1  - NICU
K1  - PICC
K1  - mechanical ventilation
K1  - high-flow nasal cannula
YR  - 2016
SP  - 57
AB  - <p>The lowest-birth-weight premature is very susceptible for nosocomial infections. These infants require the most invasive therapeutic interventions and the longest exposure to environment conductive for microbial colonization. Incidence of no-socomial infection and risk factors in pre-mature has been compared over two years, 2010 and 2015. We examined the effects of common procedures on the incidence of nosocomial sepsis. Birth weight, distribu-tion of pathogens and the therapeutically procedures had been analysed. We tried to find strategies to minimise the risks for acquiring sepsis. Hospital documentation from neonatal intensive care unit (NICU) has been analysed retrospectively dur-ing two different years in the University Hospital Osijek. Incidence of nosocomial sepsis among hospitalised premature has been 8.9% in 2010, and 4.8% in 2015. The highest rate of affected infants weighed below 1,500 g in both periods. Statistically significance in these two periods has been found in the percentage of pre-term in-fants with umbilical vein catheter (UVC), and in the number of pre-term on invasive mechanical ventilation. The most common pathogen in 2010 was methicillin-resistant Staphylococcus epidermidis (MRSE), and in 2015 coagulase negative Staphylococci (CONS). The percentage of Candida para-psylosis was higher in 2015. Lowering the incidence of late-onset sepsis has been ac-complished by using peripherally inserted central catheters (PICCs) and non-invasive mechanical ventilation. Invasive proce-dures must be avoided as much as possible.</p>