Myocardial infarction (MI) is one of the most common and important causes of heart failure in critical care and emergency medicine. Incidence of MI and MI-related mortality have been on the rise in the recent past. Metabolomics is a new field that entails analysis of profiles of metabolites (<1250 Da) in living organisms. Currently, several studies have extensively explored the application of metabolomics in medical field. In the current article, the emerging applications of next-generation metabolomics on MI in the previous 10 years were reviewed. The present article thus provides references for further use of metabolomics to guide clinical treatment and provides a basis for prevention of cardiovascular events.