Background: To analyze the correlation between Systemic immunoinflammatory index (SII), Systemic inflammatory response index (SIRI), Cluster of Differentiation 4+ T cells to Cluster of Differentiation 8+ T cells (CD4+/CD8+) ratio and children with acute attack of bronchial asthma, as well as the prognostic value. Methods: A total of 98 children with bronchial asthma admitted to our hospital from January 2020 to February 2024 were retrospectively collected. Another 50 healthy children who underwent physical examination in our hospital during the same period were selected as the control group. General data of all subjects were collected. SII, SIRI and CD4+/CD8+ ratio were collected and calculated. All the bronchial asthma children were treated with aerosol inhalation of glucocorticoids after admission. After 28 days of treatment, the patients were divided into well-controlled group and poor-controlled group. Among all the 98 patients, 65 patients were well prognosis and 32 patients were poor prognosis. Results: SII and SIRI in the disease group were significantly higher than those in the control group (p < 0.05), and CD4+/CD8+ was significantly lower p than that in the control group (p < 0.05). SII and SIRI in the poor prognosis group were significantly higher than those in the good prognosis group (p < 0.05), and CD4+/CD8+ was significantly lower than those in the good prognosis group (p < 0.05). Conclusions: SII, SIRI and CD4+/CD8+ are closely related to children with acute attack of bronchial asthma. These indicators deserve further attention in clinical practice.