Climate change is one of the most important environmental challenges of our time. Many anesthesiologists believe that inhalation anesthetics such as desflurane with its large global warming potential is a principal environmental problem of their profession and feel it is a moral imperative to eliminate its use from their own practices and to advocate for its universal prohibition. Others argue that clinical autonomy should be preserved whenever possible. Calculations based on widely accepted principles of atmospheric science present a possible resolution to this controversy. Even if desflurane were used for all of the more than 313 million surgical procedures performed each year and into the indefinite future, its effect on climate would be lost in the natural variation of global average temperature. Moreover, cessation of utilization would result in the rapid reversal of desflurane’s effects.