Article Data

  • Views 1959
  • Dowloads 133

Original Research

Open Access

Peripherally inserted central catheter complications in neonates – our experiences


1Paediatric Clinic, University Hospital Clinical Centre Banja Luka, Bosnia and Herzegovina

DOI: 10.22514/SV101.062015.3 Vol.10,Issue S1,June 2015 pp.16-19

Published: 22 June 2015

*Corresponding Author(s): STOJISLAV KONJEVIĆ E-mail:


The aim of this study was to investigate the incidence and risk factors of peripherally inserted central venous catheters (PICCs) in critically ill premature neonates; A retrospective analysis of 30 infants with very low and extremely low birth weights (VLBW, ELBW) who underwent PICC placement over a three-year period, from January 2012 till January 2015. Gestational age, birth weight (BW), sex, site of catheter placement, reason for catheter removal, duration of catheter use, proven sepsis, type of reported organism and rate of complications were collected. The infants were classified into two groups according to BWs: Group 1—VLBW infants (BW be-tween 1,000 and 1,500 g) and Group 2—ELBW infants (BW <1,000 g). During the study period PICCs were attempted in 40 patients. A PICC was successfully inserted into 30 patients (75%). PICCs placed in either the upper or the lower extremity. There were no differences in complication rates. The median time of catheter inser-tion was 13 (1-35) days for Group 1 and 11 (6-19) days for Group 2. The median du-ration of PICCs was 10.5 (2-16) and 12.2 (3-25) days. Statistical analysis showed that there was a significant difference between the groups for both catheter insertion day and mean duration of PICCs (p= 0.241, respectively). There were no significant differences between groups for the reasons for catheter removal (p=0.598). PICCs are convenient for the administration of long course antibiotics and parenteral nutrition for both VLBW and ELBW infants, but there are many risks associated with the insertion of PICCs, including serious and fatal complications.


Catheter-related infections, Cen-tral venous catheterization, Complications, Extremely low birth weight infant, Very low birth weight infant

Cite and Share

STOJISLAV KONJEVIĆ,DARIO DJUKIĆ,BARBARA STANIMIROVIĆ,ANA BLAGOJEVIĆ,VANJA BOBIĆ,BILJANA BANJA. Peripherally inserted central catheter complications in neonates – our experiences. Signa Vitae. 2015. 10(S1);16-19.


1. Shaw JL. Parenteral nutrition in the management of sick low birthweight infants. Pediatr Clin North Am 1973; 20: 333-58.

2. Riordan TP. Placement of central venous lines in the premature infant. JPEN 1979; 3: 381-2.

3. Paulson PR, Miller KM. Neonatal peripherally inserted central catheters: recommendations for prevention of insertion and postin-sertion complications. Neonatal Netw. 2008;27(4):245-257.

4. van den Hoogen A, Brouwer MJ, Gerards LJ, Fleer A, Krediet TG. Removal of percutaneously inserted central venous catheters innneonates is associated with the occurrence of sepsis. Acta Paediatr 2008;97:1250-2

5. Ohki Y, Yoshizawa Y, Watanabe M, Kuwashima M, Morikawa A. Complications of percutaneously inserted central venous cath-eters in Japanese neonates. Pediatr Int. 2008;50(5):636-639.

6. Darling JC, Newell SJ, Mohamdee O, Uzun O, Cullinane CJ, Dear PR. Central venous catheter tip in the right atrium: a risk factor for neonatal cardiac tamponade. J Perinatol. 2001;21(7):461-464.

7. Janes M, Kalyn A, Pinelli J, Hamilton BP. A randomized trial comparing peripherally inserted central venous catheters and periph-eral intravenous catheters in infants with very low birth weight. J Pediatr Surg. 2000;35(7):1040-1044.

8. Bulbul A, Okan F, Nuhoglu A. Percutaneously inserted central catheters in the newborns: a center’s experience in Turkey. J Matern Fetal Neonatal Med. 2010;23(6):529-535.

9. Stolfi I, Boccanera F, Chiara C, et al. Central venous lines and how to manage them. Early Hum Dev. 2009;85(10Suppl):S83-S84

10. Borghesi A, Stronati M. Strategies for the prevention of hospital-acquired infections in the neonatal intensive care unit. J Hosp Infect. 2008;68(4):293-300.

11. Suresh GK, Edwards WH. Central line-associated bloodstream infections in neonatal intensive care: changing the mental model from inevitability to preventability. Am J Perinatol. 2012;29(1):57-64.

12. Klein JF, Shahrivar F. Use of percutaneous silastic central venous catheters in neonates and the management of infectiouscomplica-tions. Am J Perinatol. 1992;9(4):261-264.

13. Parellada JA, Moïse AA, Hegemier S, Gest AL. Percutaneous central catheters and peripheral intravenous catheters have similar infection rates in very low birth weight infants. J Perinatol. 1999;19(4):251-254.

14. Cairns PA, Wilson DC, McClure BG, Halliday HL, McReid M. Percutaneous central venous catheter use in the very low birth weight neonate. Eur J Pediatr. 1995;154(2):145-147.

15. Hoang V, Sills J, Chadler M, Busalani E, Clifton-Koeppel R, Modanlou HD. Percutaneously inserted central catheter for total par-enteral nutrition in neonates: complications rates related to upper versus lower extremity insertion. Pediatrics. 2008;121(5):1152-1159.

16. Mahieu LM, De Muynck AO, Ieven MM, De Dooy JJ, Goossens HJ, Van Reempts PJ. Risk factors for central vascular catheter-associated bloodstream infections among patients in a neonatal intensive care unit. J Hosp Infect. 2001;48(2):108-116.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time