Signa Vitae

Print ISSN: 1334-5605 | Online ISSN: 1845-206X

The aim of Signa Vitae (SV) is to be an unbiased and permanent forum for clinical anesthesia, intensive care, emergency and pain medicine. It serves professionals dedicated to all these relevant fields, as a tool for easier and more effective experiences and science sharing, with the ultimate goal to improve patients’ outcome. The scope of Signa Vitae is broad. It encompasses all aspects of clinical practice and fundamental research at the basis of anesthesia, intensive care, emergency and pain medicine, both in children and adults. It will better inform and educate the global scientific and medical community on the advancements in the fields at the basis of survival and a better quality of life, as stated in the appealing Latin version of its name: "Signs of life".


Open Access

Antiandrogen activity of drugs for COVID-19. The case of sabizabulin

Yuki Kotani,Beatrice Righetti,Mary Ann Belli,Giovanni Landoni

DOI: 10.22514/sv.2023.027

Abstract ( 544 ) PDF (153.43 kB) ( 133 ) Full Text

Open Access Special Issue

Evidence and rationale for vaccinating children and adolescents against SARS-CoV-2: a comprehensive narrative review

Nikolaos Karantaglis,Antonios Gkantaras,Despoina Iordanidou,Eleni Volakli,Eleni Karakeke,Maria Katsafiloudi,Asimina Violaki,Maria Sdougka

DOI: 10.22514/sv.2022.055

(This article belongs to the Special Issue Pediatric Critical Care)

Abstract ( 1500 ) PDF (274.96 kB) ( 172 ) Full Text

Open Access Special Issue

Regional anesthesia for cardiothoracic surgery

Polona Gams,Juš Kšela,Maja Šoštarič

DOI: 10.22514/sv.2022.064

(This article belongs to the Special Issue Cardiothoracic anaesthesia and intensive care: current challenges and novelties)

Abstract ( 1380 ) PDF (3.79 MB) ( 382 ) Full Text

Open Access

Clinical presentation of painless pancreatitis: a systematic review

Nai-Hui Lin,Chun Chen,Hsiu-Wu Yang,Yu-Jang Su

DOI: 10.22514/sv.2023.001

Abstract ( 734 ) PDF (433.52 kB) ( 214 ) Full Text

Open Access

The prognostic value of laboratory parameters referring to hemopoietic stress in patients with COVID-19—a single center experience

István László,Mariann Berhés,Katalin Tisza,Zsófia Miltényi,Norbert Balázsfalvi,Attila Vaskó,László Asztalos,Attila Kertész,Ákos Fábián,János Kappelmayer,Béla Fülesdi

DOI: 10.22514/sv.2022.053

Abstract ( 1059 ) PDF (1.66 MB) ( 184 ) Full Text

Open Access

Correlation between income changes in the elderly receiving the basic old-age pension and suicide rates

Sun Hwa Lee,Jong Seok Oh,Duk Hee Lee,Yun Hyung Choi,Ji Yeon Lim

DOI: 10.22514/sv.2022.057

Abstract ( 1003 ) PDF (1.09 MB) ( 180 ) Full Text

Open Access

High-dose methylprednisolone versus dexamethasone therapy for hospitalized patients with severe COVID-19: a retrospective analysis

Yasumasa Kawano,Yusuke Osaki,Hiroshi Yatsugi,Tatsuya Hashimoto,Naoko Inoshima,Shuji Hayashi

DOI: 10.22514/sv.2022.065

Abstract ( 843 ) PDF (4.62 MB) ( 204 ) Full Text

Open Access Special Issue

Pulmonary embolism at the emergency department during the COVID-19 pandemic. A comparative cohort study from a tertiary level hospital in southern Spain

Antonio Jesús Láinez-Ramos-Bossini,Beatriz Moraleda Cabrera,Francisco Garrido Sanz,Elvira Ruiz Castellano,Mónica Crespo Balbuena,Francisco Javier Pérez García,Carlos Jiménez Mascuñán,Mario Rivera Izquierdo

DOI: 10.22514/sv.2022.067

(This article belongs to the Special Issue COVID-19 in the Emergency Department: Epidemiology and changes throughout the pandemic)

Abstract ( 715 ) PDF (919.9 kB) ( 169 ) Full Text

Open Access Special Issue

The quality and continuity of systemic postoperative analgesia: a single center two-stage follow-up study

Jurate Gudaityte,Laura Jazokaite,Brigita Saduikyte,Danguole Ceslava Rugyte

DOI: 10.22514/sv.2022.068

(This article belongs to the Special Issue Opioid Free Analgesia: new concept, new trends)

Abstract ( 782 ) PDF (1,019.69 kB) ( 153 ) Full Text

Open Access Special Issue

A real-world intelligent system for the diagnosis and triage of COVID-19 in the emergency department

Miguel Lastra Leidinger,Francisco Aragón Royón,Oier Etxeberria,Luis Balderas,Antonio Jesús Láinez Ramos-Bossini,Genaro López Milena,Liz Alfonso,Rosario Moreno,Antonio Arauzo,José M. Benítez

DOI: 10.22514/sv.2022.070

(This article belongs to the Special Issue COVID-19 in the Emergency Department: Epidemiology and changes throughout the pandemic)

Abstract ( 791 ) PDF (3.5 MB) ( 159 ) Full Text

Open Access

Role of lactate measurement in predicting recurrence of seizure within 24 hours in simple febrile seizure patients

Dongwook Lee,Hyung Jun Moon,Hyun Jung Lee,Dongkil Jeong,Hyun Joon Kim,Hyun Noh,Hye Young Jang,Young Soon Cho

DOI: 10.22514/sv.2023.013

Abstract ( 489 ) PDF (836.93 kB) ( 158 ) Full Text

Open Access

Analysis of the effect of health education model based on BCW theory in patients with acute retinal necrosis

Ruru Liu,Yue’e Ye,Weidan Xia,Yinghui Shi,Huarong Chen,Xiaoqiong Huang,Yanyan Chen,Yuqin Wang

DOI: 10.22514/sv.2023.033

Abstract ( 368 ) PDF (191.97 kB) ( 124 ) Full Text

Published Ahead of Print

Open Access

Barriers to the use of ultrasound guidance in central venous catheter placement by emergency physicians in Saudi Arabia: a cross-sectional study

Reema M Alhussein,Bader A Alyahya,Abdulaziz S Alashaikh,Mohammed A Malabarey,Khaled N Alrajhi,Zohair A Al Aseri

Online publish date: 09 May 2023

DOI: 10.22514/sv.2023.035

Abstract ( 323 ) PDF (303.25 kB) ( 143 ) Full Text

Open Access Special Issue

Simulation in cardiac surgery: current evidence

Joana Berger-Estilita,Ana Beatriz Noronha,Katharina Goltz,David Berger,Robert Greif

Online publish date: 09 May 2023

DOI: 10.22514/sv.2023.034

(This article belongs to the Special Issue Cardiothoracic anaesthesia and intensive care: current challenges and novelties)

Abstract ( 491 ) PDF (1.73 MB) ( 152 ) Full Text

Open Access

Pregnant and puerperal women's knowledge and awareness of venous thromboembolism: a medical of things survey technique

Abdulaziz S. Almulhim,Dalia A. Elmaghraby,Albatool Z. Al-Elaiw,Jumana T. Al-Ghaith,Tafuf A. Al-Saleh,Zainab M. Alshawaf,Naseem S. Alsuwailem,Norah A. Albanyan,Saja I. Alhawas,Zahrah H. Alsaeed,Mohammed Alabdulwahed

Online publish date: 09 May 2023

DOI: 10.22514/sv.2023.037

Abstract ( 517 ) PDF (566.17 kB) ( 135 ) Full Text

Open Access

Evaluation of time constant, dead space and compliance to determine PEEP in COVID-19 ARDS: a prospective observational study

Filip Depta,Michael A. Gentile,Richard H. Kallet,Viliam Donic,Marko Zdravkovic

Online publish date: 26 April 2023

DOI: 10.22514/sv.2023.026

Abstract ( 301 ) PDF (2.13 MB) ( 140 ) Full Text

Open Access

Anakinra for patients with COVID-19: an updated systematic review and meta-analysis

Giulio Cavalli,Paolo Navalesi,Giovanni Landoni,Andrey G. Yavorovskiy,Valery V. Likhvantsev,Alberto Zangrillo,Lorenzo Dagna,Giacomo Monti,Laura Pasin

Online publish date: 13 April 2023

DOI: 10.22514/sv.2023.025

Abstract ( 841 ) PDF (2.48 MB) ( 163 ) Full Text

Special Issues

Special issue title:

Advances in Obstetric Anaesthesia

Keywords: Obstetric Anaesthesia; Epidural Analgesia; Remifentanil-PCA; Labour and Delivery Outcomes; Quality Control in Perinatology and Obstetric Anaesthesia; ROTEM; Obstetric Haemorrhage; Preeclampsia

Editor: Prof. Tatjana Stopar Pintarič, MD, PhD, DEAA

Submission deadline: 31 May 2023

Special issue title:

Cardiothoracic anaesthesia and intensive care: current challenges and novelties

Keywords: cardiac anaesthesia, thoracic anaesthesia, intensive care, education, innovation, perioperative medicine, healthcare, outcomes, challenges

Editor: Dr. Marko Zdravkovic, MD, PhD

Submission deadline: 30 November 2022

Special issue title:

Selected papers from Korean Society of Emergency Medicine (KSEM) in 2021-2022

Keywords: Emergency medicine

Editor: Kyungwon Lee, MD, PhD,Young Duck Cho, MD, PhD

Submission deadline: 31 December 2022

Special issue title:

Medical Simulation - success in education, future of science

Keywords: medical simulation, emergency medicine, medical education

Editor: Tomasz Kłosiewicz, MD, MSc,Mateusz Puślecki, PhD

Submission deadline: 31 December 2022

Special issue title:

21st Panhellenic Congress on Regional Anaesthesia, Pain Management and Palliative Care

Keywords: Regional Anaesthesia, Pain Management, Palliative Care, PARH.SY.A., ESRA HELLAS, the A’ Anaesthesiology Department, Faculty of Medicine, University of Athens

Editor: Dr. Ioanna Siafaka, MD, PhD,Dr. Maria Kokolaki, MD, PhD,Dr. Athina Vadalouca, MD, PhD, FIPP,Dr. Evmorfia Stavropoulou, MD, PhD, EDRA,Dr. Eleni Moka, MD, PhD, MSc, EDRA

Submission deadline: 27 May 2022

Special issue title:

Selected papers from Korean Association of Cardiopulmonary Resuscitation in 2021

Keywords: Cardiac arrest, Resuscitation, cardiopulmonary resuscitation, guidelines, outcome

Editor: Prof. Won Young Kim, MD, PhD

Submission deadline: 01 June 2022

Special issue title:

Spinal Cord Injury

Keywords: Spinal cord injury (SCI), Damage mechanisms, Primary and secondary medullary lesions, Neurorehabilitation, Neurorestoration

Editor: Lecturer dr. Constantin Munteanu, PhD,Prof. Dr. Gelu Onose,Associate Prof. Dr. Mariana Rotariu, PhD,Assistant Prof. Dr. Gabriela Dogaru, PhD,Associate Prof. Dr. Elena Valentiana IONESCU, PhD,Assistant Prof. Dr. Cristina Daia, PhD

Submission deadline: 31 March 2022

Special issue title:

Outcome Measures and Assessment Tools in Spinal Cord Injury

Keywords: Spinal Cord Injury, Rehabilitation, Assessment Tools

Editor: Dr. Giovanni Galeoto

Submission deadline: 10 December 2021

Special issue title:

Opioid Free Analgesia: new concept, new trends

Keywords: Analgesia, Pain, Opioids, OFA, Regional block

Editor: Dr. Mohamed Adel Aboelela

Submission deadline: 01 April 2022

Special issue title:

Life-Threatening Clinical Situations in The Cardiac Intensive Care Unit

Keywords: Acute coronary syndrome, Cardiomyopathies, Cardiac arrhythmias, Conduction disorders, Valvular heart disease, Aortic dissection, Acute pulmonary thromboembolism

Editor: Dr. Larisa ANGHEL,Dr. Cristian STĂTESCU,Dr. Radu SASCĂU

Submission deadline: 20 February 2022

To Be a Reviewer

If you would like to review a manuscript for Signa Vitae journal, please click “Review for SV” below to register at our submission website or log in our Online Peer Review system. Your name, contact details, and expertise will be automatically added to our database of reviewers.

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Join Editorial Board

You are welcome to join our editorial board. Our journal produces and issues editorial board certificates for editorial board members, and the journal website will display the names and personal websites of editorial board members to help enhance their scientific influence. Members of the editorial committee are entitled to 1 free publication (editorial member’s or recommended paper) per year, and other articles over 2 can enjoy 30% discount of publishing fee.

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Prof. Giustino Varrassi, MD, PhD

Professor Giustino Varrassi, MD, PhD is Professor and former Chairman of the Department of Anesthesia and Pain Medicine, University of L'Aquila, Italy. At the moment, he is president of the Paolo Procacci Foundation, Roma, Italy. His scientific interest is mainly in Pain Medicine as shown by the many initiatives he has organized in his career: Founding Member (1993) and Past-President of the European Pain Federation (EFIC), where he has served in the Executive Board for 21 years; Past-President of the Italian Association for the Study of Pain, where he has served in the Council for over 30 years. In these positions, he has organized over 40 international and national congresses. Moreover, he has an intense publishing activity on Pain Medicine and other aspects of his medical specialty. More recently, he has joined NEMA Research Group. as Senior Consultant.