Aims and scope

The aim of Signa Vitae (SV) is to be an unbiased and permanent forum for clinical anesthesia, intensive care, emergency and pain medicine. It serves professionals dedicated to all these relevant fields, as a tool for easier and more effective experiences and science sharing, with the ultimate goal to improve patients’ outcome. The scope of Signa Vitae is broad. It encompasses all aspects of clinical practice and fundamental research at the basis of anesthesia, intensive care, emergency and pain medicine, both in children and adults. It will better inform and educate the global scientific and medical community on the advancements in the fields at the basis of survival and a better quality of life, as stated in the appealing Latin version of its name: "Signs of life". 


Open Access

Ibuprofen safety at the golden anniversary. A commentary and recent developments

Giustino Varrassi,Joseph V. Pergolizzi

DOI: 10.22514/sv.2020.16.0097

Abstract ( 300 ) PDF (207.1 kB) ( 25 )

Open Access Special Issue

A dangerous cause of airway obstruction: deep neck infection

Hwee-Kheng Lim,Jinn-Ming Wang,Sho-Ting Hung,Hui-Chun Ku

DOI: 10.22514/sv.2020.16.0101

Abstract ( 285 ) PDF (188.4 kB) ( 69 )

Open Access Special Issue

Diagnostic and therapeutic approach to post-traumatic tracheobronchial injuries

Angelo Carretta,Paola Ciriaco,Alessandro Bandiera,Giampiero Negri

DOI: 10.22514/sv.2021.015

Abstract ( 134 ) PDF (4.03 MB) ( 18 )

Open Access Special Issue

Extracorporeal membrane oxygenation in carbamate (methomyl) intoxication: systematic review of the literature and case presentation

Hye-Young Kim,Jun-Seok Kim,Song-Am Lee,Hyun-Keun Chee,Jae-Joon Hwang,Jin-Yong Kim,Michael Ji,Yo-Han Kim,Woo-Surng Lee

DOI: 10.22514/sv.2020.16.0090

Abstract ( 255 ) PDF (496.73 kB) ( 35 )

Open Access Special Issue

The role of rigid bronchoscopy in complex airway disorders

Alessandro Bandiera,Paola Ciriaco,Angelo Carretta,Giampiero Negri

DOI: 10.22514/sv.2021.017

Abstract ( 124 ) PDF (1.77 MB) ( 21 )

Open Access

Reliability of the Pneumonia Severity Score (PSI) Index in Patients Diagnosed with COVID-19 Pneumonia to Determine Outpatient Discharge

Ahmet Burak Erdem,Hakan Oğuztürk,Miray Tümer,Bahattin Işık,Afsin Emre Kayipmaz,Semih Korkut

DOI: 10.22514/sv.2020.16.0074

Abstract ( 371 ) PDF (241.7 kB) ( 33 )

Open Access

Chronic non-cancer pain in primary care: an Italian cross-sectional study

Arianna Camilloni,Giulio Nati,Paolo Maggiolini,Antonio Romanelli,Gianni Carbone,Diana Giannarelli,Irene Terrenato,Maria Grazia De Marinis,Adriano Rossi,Daniela D’Angelo,Rosaria Ferrara,Laura Iacorossi,Antonella Paladini,Giustino Varrassi,Gianfranco Tarsitani,Roberto Latina

DOI: 10.22514/sv.2020.16.0111

Abstract ( 541 ) PDF (356.59 kB) ( 39 )

Open Access

Dysmenorrhea is associated with a higher incidence of pain after diagnostic hysteroscopy or treatment

Yuan-Yuan Pan,Shen-Hui Jin,Shan Luo,Ru-Ru Li,Ying-Ying Tu,Dan Jin,Wen-Jun Jin,Xiu-Xiu Zhuang,Jun-Lu Wang

DOI: 10.22514/sv.2020.16.0117

Abstract ( 201 ) PDF (249.91 kB) ( 25 )

Open Access Special Issue

Predictors of survival and good neurological outcomes after in-hospital cardiac arrest

Min Jee Lee,Ji Ho Ryu,Mun Ki Min,Dae Sup Lee,Seok Ran Yeom,Byung kwan Bae,Young Mo Cho,Soon Chang Park

DOI: 10.22514/sv.2021.009

Abstract ( 125 ) PDF (365.16 kB) ( 25 )

Open Access Special Issue

Predictors of difficult endotracheal intubation in the emergency department: a single-center pilot study

En-Chih Liao,Wen-Han Chang,Ching-Hsiang Yu,Yat-Pang Chau,Fang-Ju Sun,Wen-Jyun Lai,Ding-Kuo Chien

DOI: 10.22514/sv.2020.16.0118

Abstract ( 252 ) PDF (571.95 kB) ( 44 )

Open Access Special Issue

Changes in hemodynamic parameters with the use of etomidate versus ketamine induction in the emergency department

Abdullah Bakhsh,Maryam Alnashri,Fatimah Alawami,Rafal Aseel,Maha Almaghthawi,Ghaida Alrahaili,Anas Bifari,Hassan Algethami

DOI: 10.22514/sv.2021.005

Abstract ( 187 ) PDF (570.39 kB) ( 27 )

Open Access

Challenges in basic life support and automated external defibrillator training of deaf individuals

Matej Strnad,Zdenko Šalda,Boštjan Jerko,Vida Vrečar,Vesna Borovnik Lesjak,Rok Petrovčič

DOI: 10.22514/sv.2021.019

Abstract ( 210 ) PDF (194 kB) ( 22 )

Open Access Special Issue

Antioxidative activity of statins and HDL-PON1 association in lacunar ischemic stroke with and without white matter hyperintensity

Hyun Goo Kang,Jin Sung Cheong,In Hwan Lim,Kyeong Ho Yun,Hyun Young Park

DOI: 10.22514/sv.2021.003

Abstract ( 141 ) PDF (426.79 kB) ( 21 )

Open Access

Facial expression differences indicate pain improvement at the emergency department

Kuo-Cheng Wang,Chen-June Seak,Fu-Sheng Tsai,Cheng-Yu Chien,Chi-Chun Lee,Chip-Jin Ng,Bo-Cyuan Wang,Yi-Ming Weng

DOI: 10.22514/sv.2020.16.0105

Abstract ( 340 ) PDF (508.41 kB) ( 20 )

Open Access Special Issue

Recovery from acute kidney injury is an independent predictor of survival at 30 days only after out-of-hospital cardiac arrest who were treated by targeted temperature management

Kyoung-Chul Cha,In Soo Cho,Je Hyeok Oh,Yoo Seok Park,Yoon Hee Choi,Sun Ju Kim,Tae Youn Kim

DOI: 10.22514/sv.2021.011

Abstract ( 197 ) PDF (1.95 MB) ( 24 )

Open Access Special Issue

Effects of age on emergency airway management

Sho-Ting Hung,Jerry Cheng-Yen Lai,Wen-Han Chang,Hui-Chun Ku

DOI: 10.22514/sv.2020.16.0109

Abstract ( 433 ) PDF (191.64 kB) ( 76 )

Open Access Special Issue

Determinants of complications in first ever acute stroke patients: a prospective observational study from India

Vishal Madhukar Sawale,Durjoy Lahiri,Ritwik Ghosh,Souvik Dubey,Gautam Das,Goutam Gangopadhyay,Biman Kanti Ray

DOI: 10.22514/sv.2021.002

Abstract ( 124 ) PDF (219.17 kB) ( 11 )

Open Access

Outcomes after combined right hemicolectomy and pancreaticoduodenectomy for locally advanced right-sided colon cancer: a case series

Server Sezgin Uludag,Ahmet Necati Sanli,Ozan Akinci,Deniz Esin Tekcan Sanli,Abdullah Kagan Zengin

DOI: 10.22514/sv.2020.16.0095

Abstract ( 199 ) PDF (184.68 kB) ( 12 )

Open Access

Outcomes of M. pneumoniae pneumonia with mixed infection

Cheng-Yi Wang,Lu-Min Chen,Guang-Hua Liu,Shi-Biao Wang,Qi-Qi Lin

DOI: 10.22514/sv.2020.16.0087

Abstract ( 198 ) PDF (412.26 kB) ( 15 )

Open Access

Risk factors of different types of acute pain after laparoscope-assisted vaginal hysterectomy

Si-Jia Chen,Wen-Wen Du,Yun-Chang Mo,Jun-Lu Wang,Lu-Ping Huang

DOI: 10.22514/sv.2021.010

Abstract ( 104 ) PDF (299.3 kB) ( 13 )

Open Access

Delirium in critically ill patients with COVID-19 pneumonia

Hai Zou,Wan-Feng Xiong,Sheng-Qing Li

DOI: 10.22514/sv.2021.013

Abstract ( 121 ) PDF (155.24 kB) ( 23 )

Published Ahead of Print

Open Access

Alcohol consumption and COVID-19 severity: a propensity score matched study in China

Lin Lv,Yi-Wu Zhou,Rong Yao

Online publish date: 24 February 2021

DOI: 10.22514/sv.2021.032

Abstract ( 57 ) PDF (911.72 kB) ( 11 )

Open Access

Accidental self-injection of intravenous epinephrine by healthcare personnel

Hyunseung Koh,Duk Ho Kim,Jinseong Kim,Heebum Yang

Online publish date: 24 February 2021

DOI: 10.22514/sv.2021.033

Abstract ( 38 ) PDF (725.86 kB) ( 5 )

Open Access Special Issue

Anesthetics management strategy for endovascular treatment of acute ischemic stroke. A proposal for anesthetic approach

Emanuele Russo,Daniele Bellantonio,Marco Benni,Emiliano Gamberini,Alessandro Circelli,Lorenzo Viola,Alessio Cittadini,Luca Bissoni,Dell’Amore Cristian,Martino Costanza,Giuliano Bolondi,Domenico Pietro Santonastaso,Marco Longoni,Maria Ruggiero,Vanni Agnoletti on the behalf of the Medical Emergency Team of Ospedale Bufalini Cesena

Online publish date: 22 February 2021

DOI: 10.22514/sv.2021.031

Abstract ( 44 ) PDF (153.73 kB) ( 9 )

Open Access Special Issue

Blood management in post-partum haemorrhage, including point of care coagulation tests

Martha Belete,Edmund Gerrans,Madhavi Keskar

Online publish date: 09 February 2021

DOI: 10.22514/sv.2021.030

Abstract ( 92 ) PDF (567.72 kB) ( 20 )

Open Access

Usefulness of the blood urea nitrogen-to-serum albumin ratio as a prognostic indicator of severity in acute ischemic stroke

Sung Jin Bae,Sun Hwa Lee,Seong Jong Yun,Keon Kim

Online publish date: 08 February 2021

DOI: 10.22514/sv.2021.028

Abstract ( 52 ) PDF (673.26 kB) ( 9 )

Special Issues

Special issue title:

Systemic and Cybernetic Approach to The Diagnosis and Treatment of Chronic Pain

Keywords: Chronic pain, Transdisciplinary, Systemic Cybernetic Model, Network

Editor: Dr. Leonardo Lavanderos, PhD

Submission deadline: 24 October 2021

Special issue title:

Opioid Free Analgesia: new concept, new trends

Keywords: Analgesia, Pain, Opioids, OFA, Regional block

Editor: Dr. Mohamed Adel Aboelela

Submission deadline: 20 February 2022

Special issue title:

Opioid Free Analgesia: Postoperative analgesia

Keywords: Postoperative pain, Analgesia, Opioid free, Peripheral nerve blocks

Editor: Dr. Dimosthenis Petsas

Submission deadline: 01 February 2022

Special issue title:

Anticoagulation Practice in COVID-19 Associated Coagulopathy (CAC): The Unanswered Questions

Keywords: SARS-CoV-2, COVID-19, COVID-19 associated coagulopathy, Hypercoagulability, Coagulation disorders, Thrombosis, Anticoagulants, DOACs, Heparin, Bleeding

Editor: Dr. Mohamed H. Aon

Submission deadline: 20 October 2021

Special issue title:

Acute Gout

Keywords: Gout, Colchicine, Urate-lowering drugs, Serum urate, Asymptomatic hyperuricemia

Editor: Dr. Sombat Muengtaweepongsa

Submission deadline: 31 October 2021

Special issue title:

Life-Threatening Clinical Situations in The Cardiac Intensive Care Unit

Keywords: Acute coronary syndrome, Cardiomyopathies, Cardiac arrhythmias, Conduction disorders, Valvular heart disease, Aortic dissection, Acute pulmonary thromboembolism

Editor: Dr. Larisa ANGHEL,Dr. Cristian STĂTESCU,Dr. Radu SASCĂU

Submission deadline: 20 October 2021

Special issue title:

Deep Learning for Internet of Anesthesia, Intensive Care, Emergency and Pain Medicine

Keywords: Deep learning, Artificial intelligence, Accurate diagnosis, Medical image, Anesthesia, Intensive Care, Emergency, Pain Medicine

Editor: Dr. Mazin Abed Mohammed,Dr. Korhan CENGİZ

Submission deadline: 30 December 2021

Latest tweets


SepsEast and COVID-19: Time to Make a Difference #COVID-19 #SepsEast

24 July 2020

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You are welcome to join our editorial board. Our journal produces and issues editorial board certificates for editorial board members, and the journal website will display the names and personal websites of editorial board members to help enhance their scientific influence. Members of the editorial committee are entitled to 2 free publications (both editorial member’s or recommended paper) per year, and other articles over 2 can enjoy 30% discount of publishing fee.

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  2020 has been a very special year, full of events, frequently strange and newly shaped events. As always, humanity has tried to learn from them, searching (and frequently finding) the best solution to the problems. “Work is the best gymnasium where to exercise the intelligence”. This was an excellent definition for “work”. 2020 has obliged anyone to work with new obstacles and to find always new solutions, exercising the intelligence. It is also possible to say that 2020 has provided mankind a fantastic opportunity to express at maximum level its potentialities.

  Between others, I was kindly invited to becoming Editor in Chief of this important journal. Signa Vitae has a nice story, but its aim is to increase its impact in the scientific community. The scientific community deriving from the initial “Anesthesiology”, as it was in the first decades of the twentieth century, in the course of the years has expanded enormously. Now it still covers “Anesthesiology”, but it also covers Emergency, Intensive Cares, Supportive Medicine, and last but not least Pain Medicine. In other terms, the name of the journal, Signa Vitae (“Signs of Life”, with a nuance of Latin classic culture), is extremely appropriate.

  Considering my personal story, the diffusion of Signa Vitae in the field of Pain Medicine will be a natural consequence. The new challenge will definitely be to establish a strong Editorial Board, with Section Editors, and attract high quality papers from the other branch of the medical specialty. For this, the journal counts on the support of most of the Members of the Editorial Board whose story is deeply rooted in Emergency and Intensive Cares.

  The programs for 2021 are incredibly challenging and stimulating. It will be a year of hard work and growth, and the Signa Vitae family is ready to obtain the best possible. I want to take this opportunity to thank the publisher and the Signa Vitae team for their trust in my enthusiasm, inviting me as Editor-in-Chief of a nice and promising journal. Ad majora to all of them and especially to the Authors that will be confident on the potentialities of this journal. Let’s work together for it.

Giustino Varrassi, MD, PhD

Paolo Procacci Foundation, Via Tacito 7, 00193 Roma, Italy