Neonatal early onset sepsis due to Moraxella osloensis: Case-report and revision of the literature

We report the first case of early-onset systemic neonatal infection associated with Moraxella osloensis bacteriemia in a full term baby. The genus Moraxella is constituted by a group of pleomorphic bacteria obligate aerobes, Gram-negative, oxidase positive and indole negative infrequently isolated from clinical specimens. The organism is rarely reported in the literature as the causative agent of infection in humans, mostly in immunocompromised patients. Only 12 cases of M. osloensis-related infections during childhood have been reported in the literature so far. This unique report of M. osloensis infection, during the neonatal period, concerns the isolation of the bacteria in purulent secretions from the eyes of a 3-week-old baby with opthalmia. In our patient, the precocity of the onset of symptoms allows us to hypothesize a vertical transmission of the bacteria.

Moraxella, newborn, sepsis

1. Bovre K, Henriksen SD. A new Moraxella species, Moraxella osloensis, and a revised description of Moraxella nonliquefaciens. Int J Syst Bacteriol 1967;17:127-35.

2. Berger U, Falsen E. Distribution of species of Moraxella and moraxella-like organisms in the nasopharynx of healthy human adults. Med Microbiol Immunol 1976;162:239-49.

3. Graevenitz A. Acinetobacter, Alcaligenes, Moraxella, and other nonfermentative Gram-negative bacteria. In: PR Murray, EJ Baron, MA Pfaller, FC Tenover, RH Yolken, editors. Manual of Clinical Microbiology. 6th ed. American Society for Microbiology. Washington; 2008. p. 520–32.

4. Roh KH , Kim CK , Koh E , Kim MS , Yong D , Park SC , et al. Three cases of Moraxella osloensis meningitis: a difficult experience in species identification and determination of clinical significance. J Korean Med Sci 2010;25:501-4.

5. Sung JY, Hong SK, Kim EC. The first Korean case of Moraxella osloensis bacteremia in a patient with acute myeloid leukemia. Ann Lab Med 2014;34:256-8.

6. Vuori-Holopainen E, Salo E , Saxen H , Vaara M , Tarkka E , Peltola H. Clinical “pneumococcal pneumonia” due to Moraxella osloensis: case report and a review. Scand J Infect Dis 2001;33:625-7.

7. Dien Bard J , Lewinski M , Summanen PH , Deville JG . Sepsis with prolonged hypotension due to Moraxella osloensis in a non-immunocompromised child. J Med Microbiol 2011;60:138-41.

8. Ballal M, Martena S . First case report of Moraxella osloensis diarrhea in a hemolytic uremic syndrome/acute renal failure child from rural coastal India-Manipal, Karnataka. Indian J Pediatr 2013;80:255-7.

9. Bello Gutiérrez P, Cordero Castro C, Alonso Villán E, Carvajal del Castillo O,Carabaño Aguado I, Calatayud Moscos del Prado J. Pyomyositis due to Moraxella osloensis. An Pediatr 2014;80:48-9.

10. Wyplosz B, Mihaila-Amrouche L, Baixench MT, Bigel ML, Berardi-Grassias L, Fontaine C, et al. Neonatal Moraxella osloensis Ophthalmia. Emerg Infect Dis 2005;11:1803-4.