Article Data

  • Views 583
  • Dowloads 146

Case Report

Open Access

Carbamazepine overdose presenting as a diabetes insipidus –like condition in a child

  • MADHURADHAR CHEGONDI1
  • ANDRE RASZYNSKI1
  • BALAGANGADHAR R. TOTAPALLY1

1,Division of Critical Care Medicine Nemours Children’s Hospital

DOI: 10.22514/SV102.122015.15 Vol.10,Issue 2,December 2015 pp.208-215

Published: 14 December 2015

*Corresponding Author(s): MADHURADHAR CHEGONDI E-mail: madhuradhar.chegondi@nemours.org

Abstract

overdoses it can produce various side effects involving neurological, cardiac, hematological and endocrinal systems. Inappropriate secretion of Anti Diuretic Hormone (ADH) is a well-known complication of carbamazepine toxicity. We are reporting an unusual complication in an adolescent girl with intentional carbamazepine overdose. A sixteen year old female with carbamazepine ingestion presented to our hospital with altered sensorium. On admission she was found to have a very high serum carbamazepine level and metabolic acidosis. In contrast to the possible inappropriate secretion of ADH, as an adverse effect of carbamazepine, her hospital course was complicated with a diabetes insipidus – like condition following treatment with multiple doses of activated charcoal and sodium bicarbonate therapy.

Keywords

Carbamazepine, Diabetes Insipidus, activated charcoal, child

Cite and Share

MADHURADHAR CHEGONDI,ANDRE RASZYNSKI,BALAGANGADHAR R. TOTAPALLY. Carbamazepine overdose presenting as a diabetes insipidus –like condition in a child. Signa Vitae. 2015. 10(2);208-215.

References

1. Moury JB, Spyker DA, Cantilena LR Jr, Bailey JE, Ford M. 2012 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 30th Annual Report. Clin Toxicology 2013;51:949–1229.

2. Brunton LL, JS Lazo, Parker KL. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 11th Edition., New York: McGraw-Hill; 2012. p. 511-3.

3. Stremski ES, Brady WB, Prasad K, Hennes HA. Pediatric carbamazepine intoxication. Ann Emerg Med 1995;25:624.

4. Starmer CF, Lastra AA, Nesterenko VV, Grant AO. Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments. Circulation 1991; 84:1364.

5. Soderstrom J, Murray L, Little M, Daly F FS. Toxicology case of the month: carbamazepine overdose. Emerg Med J 2006;23:869-71.

6. Amelsvoort Van Th, Bakshi R, Devaux CB, Schwabe S. Hyponatremia Associated with Carbamazepine and Oxcarbazepine Therapy: A Review. Epilepsia 1994;35(1):181-8.

7. Aggarwal A, Rastogi N, Mittal H, Chillar N, Patil R. Thyroid hormone levels in children receiving carbamazepine or valproate. Pediatr Neurol Sep 2011;45(3):159-62.

8. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 2007;356:2064-72.

9. Smith NJ, Espir ML, Baylis PH. Raised plasma arginine vasopressin concentration in carbamazepine-induced water intoxication. Br Med J 1977;2:804.

10. Bragança AC, Moyses ZP, Magaldi AJ. Carbamazepine can induce kidney water absorption by increasing aquaporin 2 expression. Nephrol Dial Transplant 2010;25(12):3840-5.

11. Wales JK. Treatment of diabetes insipidus with carbamazepine. Lancet 1975;2:948.

12. Wason S, Baker RC, Carolan P, Seigel R, Druckenbrod RW. Carbamazepine overdose – the effects of multiple dose activated charcoal. Clin Toxicol 1992;30:39-48.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

Top