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Original Research

Open Access

Epidemiology and fungal infection risk factors in patients hospitalized in neonatal and paediatric intensive care units – a multicentre pilot study


1Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia

2Department for Clinical and Molecular Microbiology, Hospital Centre Zagreb, Zagreb, Croatia

DOI: 10.22514/SV112.062016.11 Vol.11,Issue S2,June 2016 pp.51-56

Published: 14 June 2016

*Corresponding Author(s): MILIVOJ NOVAK E-mail:


Invasive fungal infections are associated with very high mortality and morbidity. Candida sp. is a leading etiological cause of invasive fungal infections (IFI). The aim of this study was to investigate the epidemiol-ogy of FI in patients admitted to neonatal and paediatric ICU (NICU and PICU) to investigate risk factors that may contrib-ute to FI development. In this retrospec-tive epidemiologic multicentre pilot study five neonatal and five paediatric intensive care units were included. The data about epidemiology, patient significant clinical data, chronic metabolic disease, surgery, mechanical ventilation, dialysis, central venous catheter, urinary catheter, arterial catheter, total parenteral nutrition, leuco-penia, neutropenia, previous antimicrobial therapy or prophylaxis were collected. In this study 25 NICU and 40 PICU patients treated with antifungal drugs during 2014 were enrolled. Among patients with fungal infection from the NICU the most often diagnosis and reason for NICU hospitali-zation was prematurity. In four NICUs C. albicans was the most common clinically significant fungal isolate. In one NICU C. parapsilosis was the most frequently iso-lated yeast. From the urine of one NICU patient with urogenital disease C. krusei was isolated. In four of five PICUs C. al-bicans was the most common cause of fungal infections. C. glabrata and C. krusei were also recorded in PICUs. In one PICU patients with clinically important moulds were recorded – patients with haematolog-ical malignancy (Fusarium sp.) and solid organ transplantation (Aspergillus spp). Thus, surveillance of epidemiology, fungal susceptibility and risk factors associated with fungal infection in a prospective mul-ticentre study could be of great value in the future. 


fungal infection, fungal epidemi-ology, risk factors for FI, paediatric patient, neonatal patient

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MILIVOJ NOVAK,SANJA PLEŠKO. Epidemiology and fungal infection risk factors in patients hospitalized in neonatal and paediatric intensive care units – a multicentre pilot study. Signa Vitae. 2016. 11(S2);51-56.


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