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Original Research

Open Access

Epidemiology and fungal infection risk factors in patients hospitalized in neonatal and paediatric intensive care units – a multicentre pilot study

  • MILIVOJ NOVAK1
  • SANJA PLEŠKO2

1Department of Paediatrics, University Hospital Centre Zagreb, Zagreb, Croatia

2Department for Clinical and Molecular Microbiology, Hospital Centre Zagreb, Zagreb, Croatia

DOI: 10.22514/SV112.062016.11 Vol.11,Issue S2,June 2016 pp.51-56

Published: 14 June 2016

*Corresponding Author(s): MILIVOJ NOVAK E-mail: mnovak@kbc-zagreb.hr

Abstract

Invasive fungal infections are associated with very high mortality and morbidity. Candida sp. is a leading etiological cause of invasive fungal infections (IFI). The aim of this study was to investigate the epidemiol-ogy of FI in patients admitted to neonatal and paediatric ICU (NICU and PICU) to investigate risk factors that may contrib-ute to FI development. In this retrospec-tive epidemiologic multicentre pilot study five neonatal and five paediatric intensive care units were included. The data about epidemiology, patient significant clinical data, chronic metabolic disease, surgery, mechanical ventilation, dialysis, central venous catheter, urinary catheter, arterial catheter, total parenteral nutrition, leuco-penia, neutropenia, previous antimicrobial therapy or prophylaxis were collected. In this study 25 NICU and 40 PICU patients treated with antifungal drugs during 2014 were enrolled. Among patients with fungal infection from the NICU the most often diagnosis and reason for NICU hospitali-zation was prematurity. In four NICUs C. albicans was the most common clinically significant fungal isolate. In one NICU C. parapsilosis was the most frequently iso-lated yeast. From the urine of one NICU patient with urogenital disease C. krusei was isolated. In four of five PICUs C. al-bicans was the most common cause of fungal infections. C. glabrata and C. krusei were also recorded in PICUs. In one PICU patients with clinically important moulds were recorded – patients with haematolog-ical malignancy (Fusarium sp.) and solid organ transplantation (Aspergillus spp). Thus, surveillance of epidemiology, fungal susceptibility and risk factors associated with fungal infection in a prospective mul-ticentre study could be of great value in the future. 

Keywords

fungal infection, fungal epidemi-ology, risk factors for FI, paediatric patient, neonatal patient

Cite and Share

MILIVOJ NOVAK,SANJA PLEŠKO. Epidemiology and fungal infection risk factors in patients hospitalized in neonatal and paediatric intensive care units – a multicentre pilot study. Signa Vitae. 2016. 11(S2);51-56.

References

1. Brissaud O, Guichoux J, Harambat J et al. Invasive fungal disease in PICU: epidemiology and risk factors. Ann Intensive Care. 2012 Feb 22;2(1):6

2. Manzoni P, Mostert M, Castagnola E. Update on the management of Candida infections in preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2015;100(5):F454-F459.

3. Jordan I, Balaguer M, López-Castilla JD. Per-species risk factors and predictors of invasive Candida infections in patients admitted to pediatric intensive care units: development of ERICAP scoring systems. Pediatr Infect Dis J. 2014 Aug;33(8):e187-e193.

4. Rangel-Frausto MS, Wiblin T, Blumberg HM et al. National epidemiology of mycoses survey (NEMIS): variations in rates of blood-stream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units. Clin Infect Dis. 1999;29(2):253-258

5. Arslankoylu AE, Kuyucu N, Yilmaz BS, et al. Symptomatic and asymptomatic candidiasis in a pediatric intensive care unit. Ital J Pediatr. 2011;21;37:56.

6. Fothergill A. W., Sutton D. A., McCarthy D. I., Wiederhold N. P. Impact of new antifungal breakpoints on antifungal resistance in Candida species. J Clin Microbiol. 2014; 52, 994–997.

7. Benjamin DK Jr, Hudak ML, Duara S, et al. Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial. JAMA 2014;311:1742–1749.

8. Hope WW, Castagnola E, Groll AH, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: preven-tion and management of invasive infections in neonates and children caused by Candida spp. Clin Microbiol Infect 2012;18(7):38–52.

9. Zaoutis TE, Argon J, Chu J et al. The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Clin Infect Dis. 2005;41:1232-1239.

10. Neu N, Malik M, Lunding A et al. Epidemiology of candidemia at a Childrens hospital, 2002 to 2006. Pediatr Infect Dis J. 2009; 28:806-809.

11. Ruhnke M. Antifungal stewardship in invasive Candida infections. Clin Microbiol Infect. 2014;20:11-18.

12. Taccone FS, Van den Abeele AM, Bulpa P et al. Epidemiology of invasive aspergillosis in critically ill patients: clinical presentation, underlying conditions, and outcomes. Crit Care. 2015;19(1):7.


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