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Case Report

Open Access

The dentist who sat on her chair and lost a leg. N2O?


1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy

2 Vita-Salute San Raffaele University, Milan, Italy

DOI: 10.22514/SV132.112017.18 Vol.13,Issue 2,November 2017 pp.116-117

Published: 06 November 2017

*Corresponding Author(s): GIOVANNI LANDONI E-mail:


A 35-year-old female dentist laid on her chair to test an N2O machine, and after only a few minutes of inhaling the N2O, she developed acute pyramidal syndrome. The patient started walking again eight months later, but still suffers from lower limb motor deficit, in spite of intensive re-habilitation. Genetic tests later showed that the patient had Type 3 homocystinuria. This is the first case report of acute neu-rological toxicity after brief administration of N2O. We suggest starting vitamin B12 and folic acid supplements promptly in pa-tients who experience neurological symp-toms after receiving N2O. 


case report, neurological toxic-ity, nitrous oxide, adverse reaction, homo-cystinuria, dental care 

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GIOVANNI LANDONI,PASQUALE NARDELLI. The dentist who sat on her chair and lost a leg. N2O?. Signa Vitae. 2017. 13(2);116-117.


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