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Case Report

Open Access

Levodopa-carbidopa-entacapone overdose presenting as altered mental status, xanthoderma, and yellowish sclera


1Department of Emergency Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea

2 Department of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Republic of Korea Correspondence:

DOI: 10.22514/SV142.102018.12 Vol.14,Issue 2,November 2018 pp.75-77

Published: 02 November 2018

*Corresponding Author(s): SEONG JONG YUN E-mail:


Levodopa-carbidopa-entacapone is a sin-gle combination drug consisting of levo-dopa (aromatic amino acid), carbidopa (dopa-decarboxylase inhibitor), and en-tacapone (catechol-O-methyltransferase inhibitor). The Food and Drug Admin-istration approved levodopa-carbidopa-entacapone in 2003, as treatment for idiopathic Parkinson’s disease in patients experiencing signs and symptoms of wear-ing-off. Although various adverse drug re-actions of levodopa-carbidopa-entacapone have been recorded, there has been no re-ported case of levodopa-carbidopa-entaca-pone overdose. We report the first case of signs and symptoms of an overdose of lev-odopa-carbidopa-entacapone (levodopa: 3000 mg; carbidopa: 750 mg; entacapone: 6000 mg) in a suicide attempt, presenting as altered mentality, xanthoderma, and yellowish sclera without hyperbilirubine-mia.


levodopa-carbidopa-entaca-pone, Parkinson’s disease, drug overdose, xanthoderma, yellowish sclera, toxicology

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SUN HWA LEE,SEONG JONG YUN,SEOKYONG RYU,SEUNG WOON CHOI,HYE JIN KIM,TAE KYUNG KANG,SUNG CHAN OH,SUK JIN CHO. Levodopa-carbidopa-entacapone overdose presenting as altered mental status, xanthoderma, and yellowish sclera. Signa Vitae. 2018. 14(2);75-77.


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