Role of Redcell Distribution Weight in Predicting Disease Severity, Mortality and Complication in Patients With Acute Pancreatitis
1Izmir Katip Çelebi University Atatürk Research and Training Hospital Emergency Department, Izmir/TURKEY
2 Izmir Katip Celebi University Atatürk Research and Training Hospital Gastroenterology Department, Izmir/TURKEY
3 Ankara Baskent University Hospital Emergency Department, Ankara/TURKEY
DOI: 10.22514/SV151.042019.9 Vol.15,Issue 1,April 2019 pp.62-66
Published: 23 April 2019
The goal of the present study was to in-vestigate the significance of the Red Cell Distribution Width (RDW) in identifying the severity, mortality and complications of the disease at an early stage in patients with acute pancreatitis (AP).
343 patients with AP presented to the emergency department during one year were included in this retrospective study. Demographic, laboratory and imaging re-sults were recorded. Bedside Index for Se-verity in AP (BISAP) score was calculated. The patients who developed pancreatitis-related mortality were recorded.
The diagnostic powers of RDW values in the diagnosis of BISAP Score (≥3), exitus, severe pancreatitis and pancreatitis with complication were analysed by means of Receiver Operating Characteristic Curve (ROC) analysis. p<0,05 was considered statistically significant.
The mean age of the subjects was 59,7 ± 18,0 years. Area under curve (AUC) in ROC analysis conducted for RDW in patients with BISAP score≥ 3 was 0,649 (95% Cl 0,576-0,722) and p <0,001. For developed complications, AUC for RDW was 0,558 (95% Cl 0,454-0,662) and p was 0,243. For RDW<14,4 cut-off value; the sensitivity was 66,25%, specificity was 71,48% in the prediction of BISAP≥ 3, sen-sitivity was 87,5%, specificity was 65,14% in the prediction of mortality, sensitivity was 72,73%, specificity was 71,12% in the prediction of severe AP.
RDW is as significant as the BISAP score in predicting the severity and mortal-ity of pancreatitis in the patients with acute pancreatitis in the emergency department(ED). But it cannot predict the complications in AP.
Emergency, acute pancreatitis, mor-tality, severity, complications, redcell distribution weight.
TAHTACI KARAALİ REZAN,TOPAL FIRDEVS,KARAKAYA ZEYNEP,PAYZA UMUT,KAVALCI CEMIL,TOPAL FATIH ESAD. Role of Redcell Distribution Weight in Predicting Disease Severity, Mortality and Complication in Patients With Acute Pancreatitis. Signa Vitae. 2019. 15(1);62-66.
1. Payman M, Kavous S.N, Mohammadhossein S, Mahboub P, Akbar F, Farzad R. Red blood cell distribution width: a determinant of hospital mortality in pancreatitis. JEPT 2018; 4(1), 2018: 34-38.
2. Ting Z, Hua L, Dongyan W, Pengfei Z, Changfeng G, Feng et al. Predicting the severity of acute pancreatitis with red cell distribution width at early admission stage. Shock.2018 May;49(5):551-555.
3. Wenzheng Z, Jiang H, Bihui Y, Xvsheng Y, Lei S, Ting Y, et al. Evaluation of Early Prognostic Factors of Mortality in Patients with Acute Pancreatitis: A Retrospective Study. Gastroenterol Res Pract 2017; 2017:1-6
4. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut 2013 Jan;62(1):102-11.
5. Sarr MG . 2012 revision of the Atlanta classification of acute pancreatitis. Pol Arch Med Wewn. 2013;123(3):118-24.
6. Jiang-Feng Y, Yu-Xin Z, Jian J, Wei W. Building and verifying a severity prediction model of acute pancreatitis (AP) based on BISAP, MEWS and routine test indexes. Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):585-591.
7. Subhash C, Arvind M, Reena B, Dipti A, Adrian H. The Bedside Index for Severity in Acute Pancreatitis: a systematic review of pro-spective studies to determine predictive performance. J Community Hosp Intern Med Perspect 2017; 7(4): 208-213.
8. Vasudevan S, Goswami P, Sonika U, Thakur B, Sreenivas V, Saraya A.. Comparison of Various Scoring Systems and Biochemical Markers in Predicting the Outcome in Acute Pancreatitis. Pancreas. 2018 Jan;47(1):65-71.
9. Biberoğlu S, Koyuncu M, Öztürk D, Toksöz A.C, ÇakmakcıE, Çakmak F, et al. Role of Computed Tomography Severity Index in Acute Diagnosis and Follow-up of Acute Pancreatitis. J Clin Anal Med 2017;8(2): 106-110.
10. Gao W, Yang HX, Ma CE. The value of BISAP score for predicting mortality and severity in acute pancreatitis. A sistematic review and meta-anlysis. PLoS One. 2015 Jun 19;10(6): e0130412.
11. Wu BU, Johannes RS, Sun X, Tabak Y, Conwell DL, Banks PA. The early prediction of mortality in acute pancreatitis: a large popula-tion-based study. Gut. 2008 Dec;57(12):1698-703
12. Vinish DB, Abishek V, Sujatha K, Arulprakash S, Solomon R, Ganesh P.Role of bedside pancreatic scores and C-reactive protein in predicting pancreatic fluid collections and necrosis. Indian J Gastroenterol. 2017 Jan;36(1):43-49.
13. Zheng J, Zhang J, Gao J. Role of bedside pancreatic scores and C-reactive protein in predicting pancreatic fluid collections and ne-crosis. Zhonghua Yi Xue Za Zhi. 2015 Mar 31;95(12):925-8.
14. Goyal H, Awad H, Hu ZD . Prognostic value of admission red blood cell distribution width in acute pancreatitis: a systematic review. Ann Transl Med. 2017 Sep;5(17):342.
15. Yang L, Liu J, Xing Y, Du L, Chen J, Liu X, et al.Comparison of BISAP, Ranson, MCTSI, and APACHE II in predicting severity and prognoses of hyperlipidemic acute pancreatitis in chinese atients. Gastroenterol Res Pract. 2016;2016:1834256
16. Kılıç MÖ, Çelik C, Yüksel C, Yıldız BD, Tez M. Correlation between Ranson score and red cell distribution width in acute pancreati-tis. Ulus Travma Acil Cerrahi Derg. 2017 Mar;23(2):112-116.
17. Şenol K, Saylam B, Kocaay F, Tez M.Red cell distribution width as a predictor of mortality in acute pancreatitis. Am J Emerg Med. 2013 Apr;31(4):687-9.
18. Yao J, Lv G.Association between red cell distribution width and acute pancreatitis: a cross-sectional study. BMJ Open. 2014 Aug 5;4(8):e004721.
19. Cakal B, Akoz AG, Ustundag Y, Yalinkilic M, Ulker A, Ankarali H.Red cell distribution width for assessment of activity of inflamma-tory bowel disease. Dig Dis Sci. 2009 Apr;54(4):842-7.
20. Uçar Karabulut K, Narcı H, Uçar Y, Uyar M.Association between Red blood cell distribution width and acute pancreatitis. Med Sci Monit. 2014 Nov 27;20:2448-52.
21. Harper S.J.F and Cheslyn-Curtis S. Acute pancreatitis. Ann Clin Biochem 2011; 48: 23–37.
22. Jo YH, Kim K, Lee JH, Kang C, Kim T, Park HM, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock. Am J Emerg Med. 2013 Mar;31(3):545-8
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.
Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.
Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.