Article Data

  • Views 1687
  • Dowloads 127

Case Report

Open Access

Platypnea-orthodeoxia-like syndrome in a septic newborn with late appearance of right congenital diaphragmatic hernia


1,University Medical Centre Ljubljana Department of Paediatric Surgery

2,University Medical Centre Ljubljana Department of Obstetrics and Gynaecology Division of Perinatology

3,University Medical Centre Ljubljana Department of Radiology

4,University Medical Centre Ljubljana Department of Thoracic Surgery

DOI: 10.22514/SV61.042011.10 Vol.6,Issue 1,May 2011 pp.50-52

Published: 02 May 2011

*Corresponding Author(s): STEFAN GROSEK E-mail:


Introduction. Cyanosis and dyspnoea with interatrial shunting of blood occurring without change in body position are termed platypnea-orthodeoxia-like syndrome.

Case presentation. We describe a female newborn with sepsis, who developed cyanosis. Two weeks after the initial appe-arance of cyanosis she presented with a right-sided diaphragmatic hernia, which was not seen on the initial X-rays. The hernia was surgically repaired. Her postoperative course was uneventful. 

Conclusions. In our case, interatrial shunting of blood was presumably caused by disturbed intrathoracic pressures. Positive pressure ventilation and sepsis may also contribute to the development of such a syndrome.


cyanosis, right-to-left shunt, infant, sepsis, congenital dia-phragmatic hernia 

Cite and Share

GORAZD MLAKAR,STEFAN GROSEK,HELENA MOLE,SILVESTER KOPRIVA,ZIVA ZUPANCIC,JANEZ PRIMOZIC,JANEZ ERZEN. Platypnea-orthodeoxia-like syndrome in a septic newborn with late appearance of right congenital diaphragmatic hernia. Signa Vitae. 2011. 6(1);50-52.


1. Burchell HB, Helmholz HF Jr, Wood EH. Reflex orthostatic dyspnea associated with pulmonary hypertension. Am J Physiol 1949;159:563–4.

2. Suzuki H, Ohuchi H, Hiraumi Y, Yasuda K, Echigo S. Effects of postural change on oxygen saturation and respiration in patients after the Fontan operation: Platypnea and orthodeoxia. Int J Cardiol 2006;106(2):211-7.

3. Pavoni D, Ragazzo S, Driussi M, Antonini-Canterin F, Pavan D, Zardo F, et al. Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein’s anomaly. Ital Heart J 2003;4(12):891-4.

4. Walther FJ, Benders MJ, Leighton JO. Persistent pulmonary hypertension in premature neonates with severe respiratory distress syndrome. Pediatrics 1992; 90:899-904.

5. Abman SH. Neonatal pulmonary hypertension: a physiologic approach to treatment. Pediatr Pulmonol Suppl 2004;26:127-8.

6. Sorrentino M, Resenkov L. Patent foramen ovale associated with platypnea and orthodeoxia Chest 1991;100(4):1157-8.

7. Bakris NC, Siddiqi AJ, Fraser CD, Mehta AC. Right-to-left interatrial shunt after pneumonectomy. Ann Thorac Surg 1997;63:198-201.

8. Godart F, Rey C, Prat A, Vincentelli A, Chma􀀁¨t A, Francart C, et al. Atrial right-to-left shunting causing severe hypoxemia despite normal right-sided pressures. Eur Heart J 2000;21:483–9.

9. Chong YM, So LY, Fok TF, Gerlis LM. Cyanotic atrial septal defect in a premature infant. Pediatr Cardiol 1991;12(1):63.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time