Parathyroid carcinoma discovered in young trauma victim during intensive care management
1,Clinical Centre of Montenegro Clinic for anaesthesia intensive care and pain therapy Ljubljanska
2,Clinical Centre of Montenegro Clinic for anaesthesia intensive care and pain therapy
3,Clinical Centre of Montenegro Clinic for surgery
4,Clinical Centre of Montenegro Institute for Pathology
DOI: 10.22514/SV61.042011.12 Vol.6,Issue 1,May 2011 pp.56-58
Published: 02 May 2011
Parathyroid gland carcinoma is uncommon disease, accounting less than 1% among the cases of primary hyperparathyro-idism. There has been reported variations in prevalence between the nations, with higher occurence in Japan and Italy, according to their referral centers. Parathyroid cancer occurs mostly in patients above 30 years, but no sex differences have been noticed. Clinical signs correspond to symptoms of hypercalcaemia, which is usually severe, due to high production of parathyroid hormone in mostly functional tumors. Palpable mass in the neck and osteoporosis are present in about 50% of the cases.
We report a case of 24-year old female victim of traffic accident, suffering severe traumatic injuries- intracerebral and bra-instem bleeding and contusions, together with femoral fracture, in which intensive care management simptoms suspicious to parathyroid carcinoma have been observed. Further imaging, laboratory findings, and clinical signs confirmed diagnosis. Surgery, with „en bloc“ excision of the node together with adherent tissue has been performed. Definite histopathology finding approved parathyroid carcinoma. Clinical signs and laboratory findings normalized in the next period, and patient was discharged from our intensive care.
This case indicates that close monitoring of clinical signs, biochemical findings together with imaging modalities available, help not to miss such rare diseases, which might be masked by primary trauma.
polytrauma, parathyroid gland, carcinoma, treatment
LJUBICA PEJAKOV,VESNA ČEJOVIĆ,ALEKSANDAR FILIPOVIĆ,TANJA NENEZIĆ. Parathyroid carcinoma discovered in young trauma victim during intensive care management. Signa Vitae. 2011. 6(1);56-58.
1. Fraker DL. Parathyroid tumors. In: DeVita VT, Jr, Hellman S, Rosenberg Sa, editors. Cancer: Principles and practice of oncology. 6th Ed. Philadelphia: Lippincott Williams and Wilkins; 2001; p. 1763-9.
2. Mittendorf EA, McHenry CR. Parathyroid carcinoma. J Surg Oncol 2005; 89(3):136-42.
3. Shattuck TM, Valimaki S, Obara T. Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma. N Engl J Med 2003; 349(18):1722-9.
4. Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med 2000;343:1863-75.
5. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1999;86(3):538-44.
6. Fraker DL. Update on the management of parathyroid tumors. Curr Opin Oncol 2000;12:41-8.
7. Shaha AR, Shah JP. Parathyroid carcinoma. A diagnostic and therapeutic challenge. Cancer 1999;86:378-80.
8. Grant CS, Thompson G. Primary hyperparathyroidism surgical management since the introduction of the minimally invasive parathyroidec-tomy. Mayo Clinic Experience. Arch Surg 2005;140:472-9.
9. Shane E. Parathyroid carcinoma. J Clin Endocrinol Metab 2001;86:485-93.
10. Bondeson L, Sandelin K, Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol 1993;17:820-9.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.
Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.
Scopus: CiteScore 0.5(2019) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.