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Open Access

Fluid balance in critically ill neonates – ways to improve it


1,Department of Paediatric Surgery and Intensive Care University Medical Centre

DOI: 10.22514/SV91.042014.5 Vol.9,Issue 1,April 2014 pp.33-36

Published: 30 April 2014

*Corresponding Author(s): DANIJELA MILANOVIC E-mail:


Fluid balance is an essential element of intensive care in critically ill neonates. Fluid and electrolyte management is carried out by constant and precise assessment of total fluid intake and output, frequent laboratory monitoring and fluid balance documenting. Accurate continuous and controlled intravenous fluid and drug administration via infusion pumps is crucial. One of the greatest “costs” of fluid and electrolyte status monitoring in critically ill neonates is the volume of blood required for its achievement. A significant volume of blood is required for laboratory testing and increases the need for red blood cell transfusions. In our retrospective observational study we evaluated the fluid balance in 30 critically ill neonates admitted to a level III multidisciplinary neonatal and paediatric intensive care unit (ICU) at the University Medical Centre Ljubljana (UMCL), between September 2011 and January 2012. The information generated by this study provided a basis for the improvement of existing management of fluid balance in critically ill neonates.


fluid balance, critically ill neonate, surgical, non-surgical

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DANIJELA MILANOVIC,MOJCA GROSELJ-GRENC. Fluid balance in critically ill neonates – ways to improve it. Signa Vitae. 2014. 9(1);33-36.


1. Kerr BA, Starbuck AL, Block SM. Fluid and electrolyte management. In: Mernstein GB, Gardner SL, eds. Handbook of Neonatal Intensive Care. 6th ed. St. Louis: Mosby Elsevier; 2006. p. 351-67.

2. Bell EF, Acarregui MJ. Fluid and electrolyte management in the newborn. Iowa Neonatology Handbook. 1994 Cited 2013, March 1. Avai-lable from:

3. Derganc M. Tekočinsko zdravljenje otroka s kirurškim obolenjem. Zdrav Vestn 1980;49:519-23.

4. Vorhaben A, Sundelwith RS. Umbilical vein catheterization. In: Shah K, Mason C, eds. Essential Emergency Procedures. Philadelphia: Lippincott Williams &Wilkins; 2008; 79: p. 374-384.

5. Biesalski HK, Bischoff SC, Boehles HJ, Muehlhoefer A. Water, electrolytes, vitamins and trace elements - Guidelines on parenteral nutrition, Chapter 7. Ger Med Sci 2009;7: Doc 21.

6. Vergnano S, Sharland M, Kazembe P, Mwansambo C, Heath PT. Neonatal sepsis: an international perspective. Arch Dis Child Fetal Neo-natal Ed 2005;90:220-4.

7. Lin JC, Strauss RG, Kulhavy JC, Johnson KJ, Zimmerman MB, Cress GA. Phlebotomy overdraw in the neonatal intensive care nursery. Pediatrics 2000;106:1-6.

8. Lorenz JM. Assessing fluid and electrolyte status in the newborn. Clin Chem 1997;43:205-10.

9. Doherty EG, Simmons CF, Jr. Fluid and electrolyte management. In: Cloherty JP, Eichenwald EC, Stark AR, eds. Manual of Neonatal Care. 6th ed. Philadelphia: Lippincott Williams &Wilkins; 2008. p. 100-14.

10. Madan A, Kumar R, Adams MM, Benitz WE, Geaghan SM, Widness JA. Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants. J Perinatol 2005;25:21-5.

11. Truog WE, Golombek SG. Principles of Management of Respiratory Problems. In: Avery GB, MacDonald MG, Seshia MMK, eds. Neona-tology: Pathophysiology and Management of the Newborn. 6th ed. Philadelphia: Lippincott Williams &Wilkins; 2005. p. 600-21.

12. Conservation. Safety. Symplicity. Edwards VAMP and VAMP jr. Systems Edwards Lifesciences LLC pamhplet. California, 2002 Cited 2013, March 1 Available from:

13. Jackson JK, Derleth DP. Effects of various arterial infusion solutions on red blood cells in the newborn. Arch Dis Child Fetal Neonatal Ed 2000;83:130-4.

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