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Case Report

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Toxic epidermal necrolysis after linezolid administration:Case report


1,Department of Anaesthesiology Reanimatology and Intensive Care Medicine University Hospital Centre Osijek

2,Department of Pathology and Forensic Medicine University Hospital Centre

DOI: 10.22514/SV92.112014.11 Vol.9,Issue 2,November 2014 pp.65-67

Published: 03 November 2014

*Corresponding Author(s): DUBRAVKA IVIĆ E-mail:


Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe skin reactions characterised by epider-mal necrolysis. Skin reactions develop as a result of drug induced keratinocyte apoptosis. Certain drugs, like nonsteroidal anti-inflammatory agents, antimicrobial substances and anticonvulsants, cause TEN or SJS more frequently. We present the case of a fatal adverse cutaneous reaction after linezolid administration in a 66-year old patient with severe staphylococcal pneumonia during treatment in the intensive care unit. According to data from the National Agency for Medicinal Products and Medical Devices of Croatia (HALMED), TEN is a rare, but not an unexpected, side effect of this antimicrobial drug. Time of occurrence, distribution and the extent of skin lesions are not typical of TEN, but the result of the postmortal skin biopsy clearly indicates the cause of the reaction.


epidermal necrolysis, toxic, linezolid, drug-related side effects and adverse reaction

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DUBRAVKA IVIĆ,KSENIJA MARJANOVIĆ,JOSIP IVIĆ,GORDANA DOŠEN. Toxic epidermal necrolysis after linezolid administration:Case report. Signa Vitae. 2014. 9(2);65-67.


1. Wolf R, Orion E, Marcos B, Matz H. Life-threatening acute adverse cutaneous drug reactions. Clinics in Dermatology 2005; 23:171-81.

2. Bachot N, Roujeau JC. Differential diagnosis of severe cutaneous drug eruptions. Am J Clin Dermatol 2003;4:561-72.

3. Pereira FA, Mudgil AV, Rosmarin DM. Toxic epidermal necrolysis. J Am Acad Dermatol 2007;56:181-200.

4. Struck MF, Hilbert P, Mockenhaupt M, Reichelt B, Steen M. Severe cutaneous adverse reactions: emergency approach to non-burn epidermolytic syndromes. Intensive Care Med 2010;36:22-32.

5. Federman DG, Enis DR, Kravetz JD, Sethi A, Heald PV, Kirsner RS. Toxic epidermal necrolysis: report of a fatal case of recurrent disease and literature review. Wounds 2005;17:296-303.

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