Gestational trophoblastic disease with multisistemic complications

Gestational trophoblastic disease (GTD) is a condition of uncertain etiology, com-prised of a hydatidiform mole (complete and partial), invasive mole, choriocarcino-ma, epithelioid trophoblastic tumour and placental site trophoblastic tumour.

A partial hydatidiform mole develops when dispermy occurs, and the resulting conceptus is triploidy. 

A 26-year-old woman (Gravida 2, Para 1, with one previous vaginal delivery of a normal female infant) was 16 weeks preg-nant and was scheduled for emergency surgical treatment. She was diagnosed with a hydatidiform mole and eclampsia in our hospital for further treatment.

Her pre-treatment beta human chorionic gonadotropin (β-HCG) level was extreme-ly high at 1,082,900 mIU/ml. The obste-tricians considered septic complications from the hydatidiform mole and we decid-ed to perform an emergency Sectio parva. Two weeks after delivery, the serum β-hCG level was 16,341 mlU/mL and normalized gradually within two months without any cytotoxic therapy.

Partial mole hydatidosa (PMH), as a milder form of GTD, can go along with malignant complications with fatal consequences.

gestational trophoblastic disease, eclampsia, chorionic gonadotropin beta sub-unit

1. Abeloff M, Armitage J, Niederhuber J. Abeloff`s clinical oncology. Philadelphia . Churchill Livingstone Elsevier. 2008

2. Allen SD, Lim AK, Seckl MJ, Blunt DM, Mitchell AW. Radiology of gestational trophoblastic neoplasia. Clinical Radiology. 2006;61(4):301–313. [PubMed]

3. Montes-de-Oca-Valero F, Macara L, Shaker A. Twin pregnancy with a complete mole and co-existing fetus following in vitro ferti-lization. Hum Reprod. 1999;14:2905–2907. [PubMed]/

4. Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z. Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol. 2005;98:19–23. [PubMed]

5. Cunningham G, Leveno C, Bloom S, Hauth J et al. Williams Obstetrics. Parkland. McGraw – Hill Professional Publishing. 2010.