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Indications for blood transfusions in critical illness 


1University Department of Anaesthesiology, Reanimatology and Intensive Care, University Hospital Centre Zagreb

DOI: 10.22514/SV101.062015.9 Vol.10,Issue S1,June 2015 pp.35-40

Published: 22 June 2015

*Corresponding Author(s): ROBERT BARONICA E-mail:


Transfusion of blood products should improve tissue oxygenation and reduce negative consequences of anaemia. At the same time, adverse effects of transfusion, such as infections, immunologic reactions and mistransfusion, could be deleterious. Most transfusion guidelines suggest look-ing at the combination of haemoglobin or haematocrit levels in addition to clinical signs in the decision making process for a blood transfusion. The problem with such indications is that the clinical evaluation may be misleading in severely ill patients and haemoglobin levels that impair oxy-gen delivery cannot be determined easily. Many studies attempted to establish more convenient parameters, such as oxygen saturation from mixed and central ve-nous blood, tissue oxygen extraction and other methods. Although the results from these studies are conflicting, it appears that global oxygenation parameters are a good indicator for a blood transfusion in some categories of critically ill patients.


haemoglobin concentration, global oxygenation parameters, transfusion, critical illness

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ROBERT BARONICA,DINKO TONKOVIĆ,BOJANA ĐUROVIĆ MRŽLJAK,LOREDANA ĐURIĆ,TIHOMIR KUŠIĆ,KAROLINA REŽEK. Indications for blood transfusions in critical illness . Signa Vitae. 2015. 10(S1);35-40.


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