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Case Report

Open Access

Epinephrine induced cardiomyopathy in a child with anaphylaxis


1Division of Critical Care Medicine and Miami Children’s Hospital, Miami, USA

2Herberth Wertheim College of Medicine, Florida International University, Miami, USA

DOI: 10.22514/SV111.052016.14 Vol.11,Issue 1,May 2016 pp.207-213

Published: 02 May 2016

*Corresponding Author(s): MADHURADHAR CHEGONDI E-mail:


Transient cardiomyopathy is an uncommon occurrence in patients with anaphylaxis. Catecholamine induced direct toxicity is one of the proposed mechanisms. We report a case of cardiomyopathy in a child with anaphylaxis who was treated with multiple doses of epinephrine as well as a continuous infusion of epinephrine. A twenty one month old girl with egg allergy presented to our hospital with anaphylaxis, after multiple doses of epinephrine injections, developed cardiorespiratory dysfunction and required endotracheal intubation and mechanical ventilation. Work up showed depressed cardiac function, which improved with milrinone and furosemide infusions. Conclusion: Epinephrine is the treatment of choice for anaphylaxis however caution should be exercised when administering multiple doses of epinephrine. Myocardial function needs to be assessed in children with persistent hypotension after anaphylaxis and catecholamine-induced cardiomyopathy should be considered in children with anaphylaxis when severe myocardial dysfunction is present.


anaphylaxis, epinephrine, cardiomyopathy, children

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MADHURADHAR CHEGONDI,ANDRE RASZYNSKI,BALAGANGADHAR R TOTAPALLY. Epinephrine induced cardiomyopathy in a child with anaphylaxis. Signa Vitae. 2016. 11(1);207-213.


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