Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Late onset perinatal sepsis in the neonatology intensive care unit – risk factors
1Clinical Hospital Centre Osijek, Department of Neonatology, Osijek, Croatia
*Corresponding Author(s): VESNA MILAS E-mail: milas.vesna@kbo.hr
The lowest-birth-weight premature is very susceptible for nosocomial infections. These infants require the most invasive therapeutic interventions and the longest exposure to environment conductive for microbial colonization. Incidence of no-socomial infection and risk factors in pre-mature has been compared over two years, 2010 and 2015. We examined the effects of common procedures on the incidence of nosocomial sepsis. Birth weight, distribu-tion of pathogens and the therapeutically procedures had been analysed. We tried to find strategies to minimise the risks for acquiring sepsis. Hospital documentation from neonatal intensive care unit (NICU) has been analysed retrospectively dur-ing two different years in the University Hospital Osijek. Incidence of nosocomial sepsis among hospitalised premature has been 8.9% in 2010, and 4.8% in 2015. The highest rate of affected infants weighed below 1,500 g in both periods. Statistically significance in these two periods has been found in the percentage of pre-term in-fants with umbilical vein catheter (UVC), and in the number of pre-term on invasive mechanical ventilation. The most common pathogen in 2010 was methicillin-resistant Staphylococcus epidermidis (MRSE), and in 2015 coagulase negative Staphylococci (CONS). The percentage of Candida para-psylosis was higher in 2015. Lowering the incidence of late-onset sepsis has been ac-complished by using peripherally inserted central catheters (PICCs) and non-invasive mechanical ventilation. Invasive proce-dures must be avoided as much as possible.
low-birth-weight pre-term in-fants, nosocomial infections, risk factors,umbilical venous catheters, NICU, PICC, mechanical ventilation, high-flow nasal cannula
HANA DOBRIĆ,VESNA MILAS,KREŠIMIR MILAS. Late onset perinatal sepsis in the neonatology intensive care unit – risk factors. Signa Vitae. 2016. 11(S2);57-60.
1. Pittet D. Infection control and quality health care in the new millenium. American Journal of Infection Control 2005; 33(5):258-267.
2. Polak J, Ringler N, Daugherty B. Unit based procedures: impact on the incidence of nosocomial infections in the newborn intensive care unit. Newborn and Infant Nursing Reviews. 2004;4(1):38-45.
3. Mahieu LM, Dooy JJ, Lenaerts AE, Ieven MM, Muynck AO. Catheter manipulations and the risk of catheter-associated bloodstream infection in neonatal intensive care unit patients. J of Hosp Infect 2001; 48(1):20-26.
4. Kawagoa JY, Segre CM, Pereira CR, Cardoso MF, Silva CV, Fukushima JT. Risk factors for nosocomial infections in critically ill new-borns: a 5-year prospective cohort study. Am J Infect Control 2001; 29(2):109-114.
5. Malveira SS, Moraes AN, Chermont AG, Costa DL, Silva TF. Recemnascidos de muito baixo peso em um hospital de referencia. Rev Para Med 2006; 20(1):41-6.
6. De Luca D, Stronati M, Jacqz-Aigrain E, Ruffinazzi G, Luparia M, Tavella E et al. Prevention of Nosocomial Infections in Neonatal Intensive Care Units. Amer J Perinatol. 2013;30(02):81-88.
7. Manzoni P, Rizzollo S, Decembrino L, et al. Recent advances in prevention of sepsis in the premature neonates in NICU. Early Hum Dev 2011; 87(1):S31-S33.
8. Gill AW, Keil AD, Jones C, Aydon L, Biggs S. Tracking neonatal nosocomial infection: the continuous quality improvement cycle. J Hosp Infect 2011;78:20-25.
9. Adams-Chapman I, Stoll BJ. Prevention of nosocomial infections in the neonatal intensive care unit. Curr Opin Pediatr 2002; 14(2):157-164.
10. Hoseini MB, Abdinia B, Rezaee MA, Oskouie SA. The study of nosocomial infection in Neonatal intensive care unit: A prospective study in Northwest Iran. Int J of Pediatrics 2014; 4(2):25-33.
11. Nanou C, Paulopoulou I, Liosis G, Tsoumakes K, Saraglou G. Risk factors for nosocomial infections in Neonatal intensive care unit (NICU). Health Science Journal 2015; 9(1):1-6.
12. Wenzel R. The Impact of Hospital-Acquired Bloodstream Infections. Emerg Infect Dis. 2001;7(2):174-177.
13. Nagata E, Brito AS, Matsuo TL. Nosocomial infection rates in a neonatal intensive care unit: Incidence and risk factors. Am J Infect Control 2002;30:26-31.
14. Stoll JB, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA et al. Late onset sepsis in very low birth weight neonates: the experience of the NICHD neonatal research Network 2002; 110(2)
15. Mahfouz AA, Al-Azraqui TA, Abbag MN, Al-Gamal MN, Seef S, Bello CS. Nosocomial infections in a neonatal intensive care unit in south-western Saudi Arabia. EMHJ 2010; 16(1):40-44.
16. Dal-Bo K, Silva RM, Sakae TM. Nosocomial infections in a neonatal intensive care unit in South Brasil. Rev Bras Ter Intensiva 2012; 24(4):381-385.
17. Dong Y,Speer C. Late-onset neonatal sepsis: recent developments. Arch Dis Child Fetal Neonatal Ed. 2014;100(3):F257-F263.
18. Mohammed D, El Seifi OS. Bacterial nosocomial infections in neonatal intensive care unit, Zagazig University hospital, Egypt. Egyp-tian Pediatric Association Gazette 2014; 62:72-79.
19. Yang LR, Peng MJ, Li H, Pang Y. Pathogen distribution and risk factors of nosocomial infections in neonates in the neonatal intensive care unit. Zhongguo Dang Dai ErKeZaZhi 2013; 15(2):112-116.
20. Turkish Neonatal Society; Nosocomial infections Study Group. Nosocomial infections in neonatal units in Turkey: epidemiology, problems, unit policies and opinions of healthcare workers. Turk J Pediatr 2010;52:50-57.
21. Golombek SG, Rohan AJ, Parvez B, Salice AL, LaGamma EF. “Proactive” management og percutaneously inserted central catheters results in decreased incidence of infection in the ELBW population. J Perinatol 2002;22:209-213.
22. Yoder B, Stoddard R, Li M, King J, Dirnberger D, Abbasi S. Heated, Humidified High-Flow Nasal Cannula Versus Nasal CPAP for Respiratory Support in Neonates. PEDIATRICS. 2013;131(5):e1482-e1490.
23. Schibler A, Pham T, Dunster K, Foster K, Barlow A, Gibbons K et al. Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery. Intensive Care Med. 2011;37(5):847-852.
24. Wing R, James C, Maranda LS, Armsby CC. Use of high-flow nasal cannula in the emergency department reduces the need for intuba-tion in pediatric acute respiratory insufiency. Ped Emergency Care 2012;28(11):1117-1123.
25. Milesi C, Boubai M, Jacquot A, Baleine J, Durand S, Oedena MP. & Cambonie G. High flow nasal cannula: recommendations for. Daily practice in pediatrics. Annals of Int Care 2014;4(1):29.
26. Kishk R, Mandour M, Farghaly R, Ibrahim A, Nemr N. Pattern of Blood Stream Infections within Neonatal Intensive Care Unit, Suez Canal University Hospital, Ismailia, Egypt. International Journal of Microbiology. 2014;2014:1-6.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.
Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.
Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.
Scopus: CiteScore 1.3 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.
Top