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Original Research

Open Access

Late onset perinatal sepsis in the neonatology intensive care unit – risk factors


1Clinical Hospital Centre Osijek, Department of Neonatology, Osijek, Croatia

DOI: 10.22514/SV112.062016.12 Vol.11,Issue S2,June 2016 pp.57-60

Published: 14 June 2016

*Corresponding Author(s): VESNA MILAS E-mail:


The lowest-birth-weight premature is very susceptible for nosocomial infections. These infants require the most invasive therapeutic interventions and the longest exposure to environment conductive for microbial colonization. Incidence of no-socomial infection and risk factors in pre-mature has been compared over two years, 2010 and 2015. We examined the effects of common procedures on the incidence of nosocomial sepsis. Birth weight, distribu-tion of pathogens and the therapeutically procedures had been analysed. We tried to find strategies to minimise the risks for acquiring sepsis. Hospital documentation from neonatal intensive care unit (NICU) has been analysed retrospectively dur-ing two different years in the University Hospital Osijek. Incidence of nosocomial sepsis among hospitalised premature has been 8.9% in 2010, and 4.8% in 2015. The highest rate of affected infants weighed below 1,500 g in both periods. Statistically significance in these two periods has been found in the percentage of pre-term in-fants with umbilical vein catheter (UVC), and in the number of pre-term on invasive mechanical ventilation. The most common pathogen in 2010 was methicillin-resistant Staphylococcus epidermidis (MRSE), and in 2015 coagulase negative Staphylococci (CONS). The percentage of Candida para-psylosis was higher in 2015. Lowering the incidence of late-onset sepsis has been ac-complished by using peripherally inserted central catheters (PICCs) and non-invasive mechanical ventilation. Invasive proce-dures must be avoided as much as possible.


 low-birth-weight pre-term in-fants, nosocomial infections, risk factors,umbilical venous catheters, NICU, PICC, mechanical ventilation, high-flow nasal cannula

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HANA DOBRIĆ,VESNA MILAS,KREŠIMIR MILAS. Late onset perinatal sepsis in the neonatology intensive care unit – risk factors. Signa Vitae. 2016. 11(S2);57-60.


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