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Original Research

Open Access

The effect of erythropoietin on chloride levels during hypoxia reoxygenation injury in rats


1Department of Gynecology, General Hospital of Thessaloniki “St. Dimitrios” Thessaloniki, Greece

2 Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, Greece

3 Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, Greece

4 Department of Biologic Chemistry, Athens University, Athens, Attiki, Greece

5 Experimental Research Centre ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, Greece

DOI: 10.22514/SV132.112017.15 Vol.13,Issue 2,November 2017 pp.97-101

Published: 06 November 2017

*Corresponding Author(s): CONSTANTINOS TSOMPOS E-mail:


Objective. This experimental study exam-ined the effect of erythropoietin (Epo) in a rat model and particularly in a hypoxia-reoxygenation (HR) protocol. The effect of that molecule was studied biochemically using blood mean chloride (Cl) levels. Materials and methods. 40 rats of mean weight 247.7 g were used in the study. Cl levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reoxygenation. Erythropoietin was admin-istered only in groups C and D.

Results. Epo administration non-signifi-cantly decreased Cl levels by 1.07%+0.91% (p=0.2635). Reoxygenation time non-significantly decreased Cl levels by 0.68%+0.92% (P= 0.4457). However, eryth-ropoietin administration and reoxygena-tion time together produced a non-signifi-cant combined effect in decreasing Cl levels by 0.74%+0.54% (P= 0.1701). Conclusions. Epo administration, reoxy-genation time and their interaction have non-significant, short-term, decreasing ef-fects on Cl levels.  


chloride, hypoxia, erythropoi-etin, reoxygenation  

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CONSTANTINOS TSOMPOS,CONSTANTINOS PANOULIS,KONSTANTINOS TOUTOUZAS,AGGELIKI TRIANTAFYLLOU,GEORGE ZOGRAFOS,APOSTOLOS PAPALOIS. The effect of erythropoietin on chloride levels during hypoxia reoxygenation injury in rats. Signa Vitae. 2017. 13(2);97-101.


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