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Original Research

Open Access

The influence of dexmedetomidine on opioid consumption in radical prostatectomy

  • KSENIJA OGRIČ1
  • NEVA POŽAR-LUKANOVIĆ1
  • MATEJ JENKO1
  • MAJA ŠOŠTARIČ'1
  • ALENKA SPINDLER-VESEL1

1Department of Anaesthesiology and Surgical Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia

DOI: 10.22514/SV132.112017.16 Vol.13,Issue 2,November 2017 pp.102-107

Published: 06 November 2017

*Corresponding Author(s): ALENKA SPINDLER-VESEL E-mail: alenka.spindler@guest.arnes.si

Abstract

Objective. Multimodal analgesia and anal-gesics with different modes of action can reduce perioperative opioid demand and their undesirable side effects. 

In our study we presumed that patients anesthetised with additional perioperative dexmedetomidine infusion, during radi-cal prostatectomy, would need less opioids during and after surgery compared to the control group.

Materials and methods. 40 patients, 18-80 years of age, ASA class 1-3 (American So-ciety of Anesthesiologists), scheduled for radical prostatectomy, were included in the study. Patients were randomly divided into two groups (20 pts in each group). In both groups, fentanyl in repeated boluses was used as an analgesic; in the studied group, an additional infusion of dexme-detomidine (0.3 µg/kg/h) was started with intravenous line insertion and continued until the beginning of wound closure. An-algesic consumption during the operation, in the post-anaesthesia care unit, in the In-tensive Care Unit on the day of the opera-tion and on the first postoperative day was recorded.

Results. The patients with perioperative dexmedetomidine infusion were slightly younger (p=0.007), also the duration of their surgery was shorter (p =0.05). Differ-ences in opioid consumption between the groups were not found. Also, pain assess-ment, by visual analogue scale (VAS) after 12, 18, 24, 30, 36 and 42 hours, was not sta-tistically different between groups. Conclusion. In our study, perioperative dexmadetomidine did not reduce peri- and postoperative opioid consumption. Also, undesirable dexmedetomidine side effects, such as bradycardia and hypoten-sion, were not observed.

Keywords

dexmedetomidine, radical pros-tatectomy 

Cite and Share

KSENIJA OGRIČ,NEVA POŽAR-LUKANOVIĆ,MATEJ JENKO,MAJA ŠOŠTARIČ',ALENKA SPINDLER-VESEL. The influence of dexmedetomidine on opioid consumption in radical prostatectomy. Signa Vitae. 2017. 13(2);102-107.

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