Can partial splenectomy preserve humoral immunity in pediatric patients? Risks and benefits of partial splenectomy
1Division of Pediatric Oncology, Catholic University of Rome, A. Gemelli Hospital, Rome, Italy
2 Department of Pediatric Haemato-Oncology, Ospedale G.Salesi, Ancona, Italy
3 Division of Pediatric Surgery, Catholic University of Rome, A. Gemelli Hospital, Rome, Italy
DOI: 10.22514/SV141.052018.2 Vol.14,Issue 1,March 2018 pp.17-19
Published: 27 March 2018
The spleen plays an important role in re-moving normal and abnormal cells from the blood and in providing an immuno-logic response to encapsulated bacteria. Surgical splenectomy provides effective treatment for several pediatric disorders, such as congenital and acquired hemolytic anemias, abdominal traumas and immu-nological and metabolic disorders, but it is associated with an immediate and life-long risk of overwhelming infection. An alternative to conventional splenectomy is partial splenectomy, recommended espe-cially in children younger than 5 years of age. Recommendations for the prevention of overwhelming post-total splenectomy infection include: Pneumococcal, Haemo-philus influenzae type B and Meningococ-cal immunizations, antimicrobial prophy-laxis and prompt antibiotic treatment of acute febrile illness; conversely, there is no clear evidence indicating which preven-tion measures are to be performed in pa-tients undergoing partial splenectomy.
partial splenectomy, children, immunization
MARTINA CATALANO,DANIELA RIZZO,PAOLA COCCIA,PALMA MAURIZI,LORENZO NANNI,ANTONIO RUGGIERO. Can partial splenectomy preserve humoral immunity in pediatric patients? Risks and benefits of partial splenectomy. Signa Vitae. 2018. 14(1);17-19.
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