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Can partial splenectomy preserve humoral immunity in pediatric patients? Risks and benefits of partial splenectomy


1Division of Pediatric Oncology, Catholic University of Rome, A. Gemelli Hospital, Rome, Italy

2 Department of Pediatric Haemato-Oncology, Ospedale G.Salesi, Ancona, Italy

3 Division of Pediatric Surgery, Catholic University of Rome, A. Gemelli Hospital, Rome, Italy

DOI: 10.22514/SV141.052018.2 Vol.14,Issue 1,March 2018 pp.17-19

Published: 27 March 2018

*Corresponding Author(s): ANTONIO RUGGIERO E-mail:


The spleen plays an important role in re-moving normal and abnormal cells from the blood and in providing an immuno-logic response to encapsulated bacteria. Surgical splenectomy provides effective treatment for several pediatric disorders, such as congenital and acquired hemolytic anemias, abdominal traumas and immu-nological and metabolic disorders, but it is associated with an immediate and life-long risk of overwhelming infection. An alternative to conventional splenectomy is partial splenectomy, recommended espe-cially in children younger than 5 years of age. Recommendations for the prevention of overwhelming post-total splenectomy infection include: Pneumococcal, Haemo-philus influenzae type B and Meningococ-cal immunizations, antimicrobial prophy-laxis and prompt antibiotic treatment of acute febrile illness; conversely, there is no clear evidence indicating which preven-tion measures are to be performed in pa-tients undergoing partial splenectomy.


partial splenectomy, children, immunization

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MARTINA CATALANO,DANIELA RIZZO,PAOLA COCCIA,PALMA MAURIZI,LORENZO NANNI,ANTONIO RUGGIERO. Can partial splenectomy preserve humoral immunity in pediatric patients? Risks and benefits of partial splenectomy. Signa Vitae. 2018. 14(1);17-19.


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