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Case Report

Open Access

Late-onset sick sinus syndrome after carbon monoxide poisoning


1Komoro Kosei General Hospital, Yoramachi, Komoro, Japan

DOI: 10.22514/SV142.102018.11 Vol.14,Issue 2,November 2018 pp.73-74

Published: 02 November 2018

*Corresponding Author(s): YUYA KOBAYASHI E-mail:


Carbon monoxide (CO) is a known, potent poisonous gas that causes hypoxaemia be-cause of its high affinity for haemoglobin. It also induces inflammatory responses that cause tissue injury, particularly to the nervous and cardiovascular systems. Here we present a case of late-onset sick sinus syndrome (SSS) after CO poisoning. Ar-rhythmia during the acute phase has been recorded in the literature, but to the best of our knowledge, this is the first report of late-onset SSS. Late-onset neuropathy after CO poisoning is well known, and it seems that a similar mechanism develops in car-diac conduction after CO poisoning. This report highlights the importance of follow-up for arrhythmia after CO poisoning. 


sick sinus syndrome, carbon monoxide poisoning, arrhythmia, neuro-logic injury, cardiac injury

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YUYA KOBAYASHI,YASUFUMI KONDO,JUN TSUYUZAKI,TAKAYUKI EIZAWA. Late-onset sick sinus syndrome after carbon monoxide poisoning. Signa Vitae. 2018. 14(2);73-74.


1. Weaver LK. Carbon monoxide poisoning. N Engl J Med 2009;360:1217–25.

2. Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002;347:1057–67.

3. Mannaioni PF, Vannacci A, Masini E. Carbon monoxide: the bad and the good side of the coin, from neuronal death to anti-inflammatory activity. Inflamm Res 2006;55:261–73.

4. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, et al. Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 2003;278:1248–58.

5. Taillé C, Almolki A, Benhamed M, Zedda C, Mégret J, Berger P, et al. Heme oxygenase inhibits human airway smooth muscle pro-liferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. J Biol Chem 2003;278:27160–8.

6. Suliman HB, Carraway MS, Tatro LG, Piantadosi CA. A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 2007;120:299–308.

7. Thom SR. Hyperbaric-oxygen therapy for acute carbon monoxide poisoning. N Engl J Med 2002; 347:1105-6.

8. Henry CR, Satran D, Lindgren B, Adkinson C, Nicholson CI, Henry TD. Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning. JAMA 2006;295:398–402.

9. Satran D, Henry CR, Adkinson C, Nicholson CI, Bracha Y, Henry TD. Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. J Am Coll Cardiol 2005;45:1513–6.

10. Lee FY, Chen WK, Lin CL, Kao CH. Carbon monoxide poisoning and subsequent cardiovascular disease risk: a nationwide popu-lation-based cohort study. Medicine (Baltimore) 2015;94:e624.

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