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Original Research

Open Access

Total plasma sulfide in mild to moderate diastolic heart dysfunction

  • NINA GLAVNIK POZNIČ1
  • DRAGAN KOVAČIĆ1
  • TOMAŽ GOSLAR2,5
  • TOMAŽ MARŠ3,5
  • MATEJ PODBREGAR4,5

1Department of Cardiology, General Hospital Celje, Celje, Slovenia

2 Centre for Intensive Care Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia

3 Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

4 Clinical Department for Anaesthesiology and Surgical Intensive Care, University Medical Centre Ljubljana, Ljubljana, Slovenia

5 Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

DOI: 10.22514/SV142.102018.5 Vol.14,Issue 2,November 2018 pp.35-40

Published: 02 November 2018

*Corresponding Author(s): NINA GLAVNIK POZNIČ E-mail: nina_glavnik@yahoo.com

Abstract

mechanisms of diastolic dysfunction are not understood well. Hydrogen sulfide is an important endogenous gaseous trans-mitter that can influence heart remodeling. The aim was to determine total plasma sulfide (TPS) levels, as a surrogate marker of hydrogen sulfide, in patients with mild diastolic dysfunction.

Methods. Total plasma sulfide and N-ter-minal pro brain-type natriuretic peptide (NT-proBNP) levels were determined in ambulatory patients with arterial hyper-tension or diabetes mellitus and echocar-diographically mild to moderate diastolic dysfunction.

Results. Twenty-four patients were in-cluded: nine with normal diastolic func-tion (Grade 0), eight with an impaired relaxation pattern (Grade 1), and seven with a pseudo-normalized pattern (Grade 2). TPS levels were highest in patients with normal diastolic function (Grade 0), and lowest in patients with Grade 2 diastolic dysfunction, with this difference between Grade 0 and Grade 2 showing statistical significance (p = 0.017). NT-proBNP lev-els showed the reverse behavior, with this difference again showing statistical signifi-cance (p = 0.042).

Conclusions. Total plasma sulfide levels decrease with worsening of diastolic func-tion from normal to moderate diastolic dysfunction. 

Keywords

total plasma sulfide, hydrogen sulfide, arterial hypertension, diastolic dys-function, echocardiography

Cite and Share

NINA GLAVNIK POZNIČ,DRAGAN KOVAČIĆ,TOMAŽ GOSLAR,TOMAŽ MARŠ,MATEJ PODBREGAR. Total plasma sulfide in mild to moderate diastolic heart dysfunction. Signa Vitae. 2018. 14(2);35-40.

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