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Human protein C concentrates in adult septic patients


1,Department of Cardiothoracic Anesthesia and Intensive Care Istituto Scientifico San Raffaele

DOI: 10.22514/SV32.102008.1 Vol.3,Issue 2,October 2008 pp.13-17

Published: 01 October 2008

*Corresponding Author(s): GIOVANNI LANDONI E-mail:


Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C). 


sepsis, protein C, cardiac surgery

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GIOVANNI LANDONI,MARTINA CRIVELLARI,GIACOMO MONTI,CHIARA GERLI • PAOLO SILVANI,ALBERTO ZANGRILLO. Human protein C concentrates in adult septic patients. Signa Vitae. 2008. 3(2);13-17.


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