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Human protein C concentrate in pediatric septic patients


1,Department of Anesthesia and Intensive Care Università Vita-Salute San Raffaele Milano

DOI: 10.22514/SV51.042010.2 Vol.5,Issue 1,April 2010 pp.13-19

Published: 27 April 2010

*Corresponding Author(s): GIOVANNI LANDONIĆ E-mail:


Severe sepsis and septic shock are leading causes of morbidity and mortality in the pediatric population. Unlike what is suggested for the adult population, recombinant human activated protein C (rhAPC) is contraindicated in children. Long before rhAPC was considered for use in pediatric patients, case reports appeared on the safe administration of protein C zymogen. Therefore, we conducted a systemic review of currently available data on protein C zymogen (PC) use among children affected by severe sepsis or septic shock. 

A total number of 13 case series or case reports and a dose-finding study were found on the use of PC in the pediatric intensive care unit, reporting on 118 treated children, with an overall survival of 84%. There was no bleeding complication, the only reported complication being a single mild allergic reaction.

These studies show that PC is safe, not associated with bleeding and possibly useful for improving coagulation abnormali-ties of sepsis.


sepsis, pediatric, protein C, drug therapy, review

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