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Nesiritide and clinically relevant outcomes in cardiac surgery: a meta-analysis of randomized studies


1,Department of Anesthesia and Intensive Care Università Vita-Salute San Raffaele

2,Interventional Cardiology Division of Cardiology University of Turin

DOI: 10.22514/SV62.102011.2 Vol.6,Issue 2,October 2011 pp.17-23

Published: 31 October 2011

*Corresponding Author(s): GIULIA MAJ E-mail:


B-type natriuretic peptide is a cardiac hormone that relaxes vascular smooth muscle and causes arterial dilatation. Nesiritide has been associated with increased urine output; reduced diuretic requirements; and suppression of aldosterone, endot-helin, and norepinephrine. We have independently conducted the first systematic review and meta-analysis of randomized trials to determine the impact of nesiritide on renal replacement therapy and death in patients undergoing cardiac surgery. We performed a meta-analysis of 6 randomized controlled studies including 560 patients (280 receiving nesiritide and 280 assigned to the control group). Two unblinded reviewers selected randomized trials studying nesiritide in patients undergoing cardiac surgery. Nesiritide doses ranged from 0.005 mcg/kg/min to 0.01 mcg/kg/min. Nesiritide did not reduce postoperative creatinine peak values: -0.16 [-0.42, 0.10], p for effect=0.23, p for heterogeneity<0.01, I2=90.5%) or the need for renal replacement therapy (1/177 in the nesiritide group vs 4/176 in the control group OR 0.39 [0.07, 2.06], p for effect=0.27, p for heterogeneity=0.70, I2=0%). We observed an interesting trend toward a reduction in mortality in the nesiritide group:13/280 (4.6%) vs 22/280 (7.8%) OR 0.57 [0.28, 1.15], p for effect=0.12, p for heterogeneity=0.43, I2=0%. Nesiritide did not reduce time of mechanical ventilation -8.77 hours [-21.42, 3.88], p=0.17, length of hospital stay -2.67 days [-6.50, 1.16], p=0.17 or intensive care unit (ICU) stay -0.94 days [-2.83, 0.95], p=0.33. In conclusion, further randomized controlled trials are needed to support the hypothesis that nesiritide improves clinically relevant outcomes in cardiac surgery.


Nesiritide, meta-analysis, cardiac surgery, renal replacement therapy, mortality

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GIULIA MAJ,GIOVANNI LANDONI,GIUSEPPE BIONDI-ZOCCAI,ELENA BIGNAMI,LUCA CABRINI,LUCA BURATTI,MASSIMILIANO GRECO,MASSIMO ZAMBON,ALBERTO ZANGRILLO. Nesiritide and clinically relevant outcomes in cardiac surgery: a meta-analysis of randomized studies. Signa Vitae. 2011. 6(2);17-23.


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