Terlipressin/adrenaline is better than adrenaline alone in a porcine model of prolonged ventricular fibrillation
A randomized controlled study
1Department of Anaesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove
2Department of Anaesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove
3Emergency Medical Services of the Central Bohemian Region, Beroun, Czech Republic /Department of Anaesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove
4Department of Anesthesia, Dalhousie University
5Department of Anaesthesiology and Intensive Care Medicine, Ernst Moritz Arndt University
6Department of Anaesthesiology and Intensive Care, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Czech Republic /Department of Anesthesia, Dalhousie University
DOI: 10.22514/SV71.042012.2 Vol.7,Issue 1,April 2012 pp.10-16
Published: 30 April 2012
Objectives. Vasopressors have been routinely used in cardiopulmonary resuscitation. Recent data show that terlipressin may restore blood pressure in asphyxial and prolonged arrests but its potential role in ventricular fibrillation (VF) remains unknown. The aim of this study was to compare coronary (CorPP) and cerebral (CPP) perfusion pressures achieved by terlipressin/adrenaline versus placebo/adrenaline in VF.
Methods. Fourteen domestic pigs were randomly assigned into group A and B. After 5 min of untreated VF, compression-only resuscitation was applied for 10 min, followed by advanced life support. Terlipressin in a single-dose of 30 g·kg-1 was added to the first dose of adrenaline in group A, while placebo was given in group B. CorPP and CPP were calcula-ted from right atrial, aortic and intracerebral pressures. Data were analyzed using repeated measurements ANOVA and a Fisher´s protected LSD post hoc test.
Results. Terlipressin/adrenaline maintained CorPP above 10 mmHg for 17.7 min longer than adrenaline alone (P=0.003) unable to prevent refractory hypotension. CorPP (mean±SD) measured at 35, 45, and 55 min after the onset of VF was 12 ± 4, 11 ± 6, and 10 ± 5 mmHg in the terlipressin group A; and 6 ± 4, 1 ± 5, and -1 ± 5 mmHg in placebo group B (P=0.03, <0.001, and <0.001). CPP measured at the same times was 23 ± 7, 20 ± 7, and 23 ± 7 mmHg in group A; and 13 ± 7, 6 ± 5, and 6 ± 7 mmHg in group B (P=0.01, <0.001, and <0.001).
Conclusion. The study showed that a single dose of terlipressin, when added to adrenaline, was effective for achievement of higher vital organ perfusion pressures compared to adrenaline alone.
cardiopulmonary resusci-tation (CPR), cardiac arrest, terlipre-ssin, vasopressor therapy, cerebral perfusion pressure, coronary perfu-sion pressure, ventricular fibrillation
ANATOLIJ TRUHLAR,ZDENEK TUREK,ROMAN SKULEC,CHRISTIAN LEHMANN ,DRAGAN PAVLOVIC,VLADIMIR CERNY. Terlipressin/adrenaline is better than adrenaline alone in a porcine model of prolonged ventricular fibrillationA randomized controlled study. Signa Vitae. 2012. 7(1);10-16.
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