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The effects of post-intubation hypertension in severe traumatic brain injury


1,Department of Emergency Medicine Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Emergency Medicine Chang Gung Memorial Hospital

DOI: 10.22514/SV82.102013.4 Vol.8,Issue 2,October 2013 pp.24-29

Published: 17 October 2013

*Corresponding Author(s): CHIH-CHUAN LIN E-mail:


Introduction. The effect of post-intubation hypertension in severe traumatic brain injury (TBI) patients remains uncertain. We aimed to determine the relationship between post-intubation hypertension (mean arterial pressure (MAP) > 110mmHg) and outcomes in severe TBI. 

Methods. In this retrospective cohort study, adults who presented with isolated TBI and a MAP 􀀁 70mmHg were assessed. Data were retrieved from our institutional trauma registry and the admission list of our neurosurgical intensive care unit (ICU). Results. We enrolled 126 patients, 81 of whom had a MAP 􀀂 110 mmHg after intubation and were assigned to group 1; 45 patients who had a MAP > 110 mmHg were assigned to group 2. Only age (P = 0.008), heart rate (HR; P = 0.036), and MAP before intubation (P < 0.001) were significantly different between groups. We found no significant intergroup differences in mortality (35.8 vs. 35.6%, P = 1.000) or in the motor function of survivors at discharge (P = 0.333). The length of ventilator-dependent (median: 2.0 vs. 5.0 days; P = 0.003) and ICU stays (median: 4.5 vs. 10.0 days; P = 0.005) were significantly longer in group 2. Post-intubation hypertension remained significantly associated with longer ICU stay (􀀁 7 days) and poor neurologic outcome (motor < 4 at discharge) after adjusting for other variables (post-intubation MAP >110 mmHg, P < 0.034, OR 3.119, 95% CI 1.087–8.953). 

Conclusion. Post-intubation hypertension was associated with longer ventilator-dependent and ICU stays in patients with severe TBI. 


endotracheal intubati-on, hemodynamics, blood pressure, mean arterial pressure, intracranial hemorrhage

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CHIEN-WEI CHENG,YI-MING WENG,CHIH-CHUAN LIN,CHING-I KUO ,CHI-CHUN LIN. The effects of post-intubation hypertension in severe traumatic brain injury. Signa Vitae. 2013. 8(2);24-29.


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