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Original Research

Open Access

Correlation between mean platelet volume and total risk of cardiovascular disease

  • DOMAGOJ MARKOVIĆ1
  • VEDRAN CAREVIĆ2
  • DAMIR BONACIN2
  • BRANKA PAUKOVIĆ SEKULIĆ3
  • ADA SAPUNAR3
  • DAMIR FABIJANIĆ2

1Traffic Technical School, Split

2,Department of Internal Medicine University Hospital Split

3,Department of Biochemistry and Laboratory medicine University Hospital Split

DOI: 10.22514/SV82.102013.8 Vol.8,Issue 2,October 2013 pp.49-55

Published: 17 October 2013

*Corresponding Author(s): DAMIR FABIJANIĆ E-mail: damir.fabijanic@st.t-com.hr

Abstract

Introduction. The association between mean platelet volume (MPV) and single cardiovascular disease (CVD) risk factors has previously been tested. The aim of our study was to evaluate the association between MPV and total risk of CVD. Materials and Methods. In 216 consecutive outpatients referred for a cardiology assessment because of multiple CVD risk factors, total CVD risk was estimated according to the Framingham Risk Score (FRS) as low (<10%), intermediate (11-19%), and high (>20%). Additionally, FRS was adjusted for triglycerides (TG), body mass index (BMI) and a family history of CVD, important CVD risk factors which are not included in the FRS equation. Also, CVD risk was estimated according to terciles of MPV (<8.3, 8.3-9.1, >9.1 fL, respectively). Correlation between high sensitivity C-reactive protein (hs-CRP) and FRS was used as confirmation that our study hypothesis was properly set.

Results. MPV did not correlate with individual CVD risk factors or with FRS, either before, or after adjustment for additional CVD risk factors. Significant correlation between MPV and total CV risk was observed only in the adjusted high FRS group; namely, for persons in tercile 3, CVD risk was doubled (OR 2.2; 95% CI 1.05-4.64; P =0.038). In comparison, there was a strong linear correlation between hs-CRP and unadjusted (r=0.203, P=0.004) and adjusted (r=0.383, P<0.001) FRS. Conclusion. Correlation between MPV and high total CVD risk suggests increased platelet activity primarily as a consequ-ence and sign of atherosclerotic vascular damage. Linear correlation between hs-CRP with FRS confirms inflammation as an important mechanism of atherogenesis.

Keywords

platelets, atherosclero-sis, coronary risk prediction, Framin-gham risk score.

Cite and Share

DOMAGOJ MARKOVIĆ,VEDRAN CAREVIĆ,DAMIR BONACIN,BRANKA PAUKOVIĆ SEKULIĆ,ADA SAPUNAR,DAMIR FABIJANIĆ. Correlation between mean platelet volume and total risk of cardiovascular disease. Signa Vitae. 2013. 8(2);49-55.

References

1. Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil 2007;14(Suppl 2):S1-113.

2. Grundy SM, Balady GI, Criqui MH, Fletcher G, Greenland P, Hiratzka LF, et al. Primary prevention of coronary heart disease: guidance from Framingham: a statement for healtcare professionals from the AHA Task Force on Risk Reduction. Circulation 1998;97:1876-87.

3. Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW, Konkle B, et al. Mean platelet volume as predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148-56.

4. Inanc T, Kaya MG, Yarlioglues M, Ardic I, Ozdogru I, Dogan A, et al. The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives. Blood Press 2010;19:81-5.

5. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets 2006;17:350.

6. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK, et al. Mean platelet volume in type 2 Diabetes mellitus. J Lab Physician 2012;4:5-9.

7. Grotto HZW, Noronha JFA. Platelet larger cell ratio (P-LCR) in patients with dyslipidemia. Clin Lab Haematol 2004;6:347-49.

8. Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Practice 2004;59:981-2.

9. Albert MA, Glynn RY, Ridker PM. Plasma Concentration of C-Reactive Protein and the Calculated Framingham Coronary Heart Disease Risk Score. Circulation 2003;108:161-5.

10. Libby P, Ridker PM, Maseri A. Inflammation and Atherosclerosis. Circulation 2002;105:1135-43.

11. Shahin Y, Hatfield J, Chetter I. C-reactive protein and the Framingham coronary risk core in patients newly diagnosed with intermittent claudication: a prospective study. Vasc Endovascular Surg 2012;46:242-5.

12. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, et al. Characterization of the proteins released from activated platelets leads to localizationof novel platelet in human atherosclerotic lesions. Blood 2004;103:2096-104.

13. Margetic S. Inflammation and haemostasis. Biochem Med (Zagreb) 2012;22:49-62.

14. Ates O, Kiki I, Bilen H. Association of mean platelet volume with the degree of retinopathy in patients with diabetes mellitus. Eur J Gen Med 2009;6:99-102.

15. Yarlioglues M, Kaya MG, Ardic I, Dogdu O, Kasapkara HA, Gunturk E, et al. Relationship between mean platelet volume levels and subcli-nical target organ damage in newly diagnosed hypertensive patients. Blood Press 2011;20:92-7.

16. Kutlucan A, Bulur S, Kr S, Bulur S, Önder E, Aslanta􀀄 Y, et al. The relationship between mean platelet volume with metabolic syndrome in obese individuals. Blood Coagul Fibrinolysis 2012;23:388-90.

17. Vazzana N, Santilli F, Sestili S, Cuccurullo C, Davi G. Determinants of increased cardiovascular disease in obesity and metabolic syndrome. Curr Med Chem 2011;18:5267-80.

18. Dogan A, Aksoy F, Icli A, Arslan A, Varol E, Uysal BA, et al. Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation. Blood Coagul Fibrinolysis 2012;23:324-30.

19. Thiruvagounder M, Khan S, Sheriff DS. The prevalence of metabolic syndrome in a local population in India. Biochem Med (Zagreb) 2010;20:249-52.

20. Chu H, Chen WL, Huang CC, Chang HY, Kuo HY, Gau CM, et al. Diagnostic performance of mean platelet volume for patients with acute coronary syndrome visiting an emergency department with acute chest pain: the Chinese scenario. Emerg Med J 2011;28:569-74.

21. Dekker JM, Crow RS, Folsom AR, Hannan PJ, Liao D, Swenne CA, et al. Atherosclerosis risk in communities. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Circulation 2000;102:1239-44.

22. Kupari M, Virolainen J, Koskinen P, Tikkanen MJ. Short-term heart rate variability and factors modifying the risk of coronary artery disease in a population sample. Am J Cardiol 1993;72:897-903.

23. Thayer JF, Yamamoto SS, Brosschot JF. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol 2010;141:122-31.

24. Yoo CS, Lee K, Yi SH, Kim JS, Kim HC. Association of heart rate variability with the framingham risk score in healthy adults. Korean J Fam Med 2011;32:334-40.

25. Bakovi􀀃 D, Pivac N, Eterovi􀀃 D, Palada I, Valic Z, Paukovic-Sekulic B, et al. Changes in platelet size and spleen volume in response to selective and non-selective beta-adrenoreceptor blockade in hypertensive patients. Clin Exp Pharmacol Physiol 2009;36:441-6.

26. Coban E, Afacan B. The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelet 2008;19:111-4.

27. Jagroop IA, Mikhailidis DP. Angiotensin II can induce and potentiate shape change in human platelets: effect of losartan. J Hum Hypertens 2000;14:581-5.

28. Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology 2006;11:317-9.

29. Macey M, Azam U, McCarthy D, Webb L, Chapman ES, Okrongly D, et al. Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine, and dipyridamole (CTAD) for assessing platelet activation on the ADVIA 120 haematology system. Clin Chem 2002;48:891-9.

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