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Original Research

Open Access

Risk factors for developing epilepsy after neonatal seizures


1,Clinical Department of Neonatology Division of Paediatrics University Medical Centre Ljubljana

2Clinical Department of Child, Adolescent and Developmental Neurology Division of Paediatrics University Medical Centre Ljubljana

DOI: 10.22514/SV91.042014.6 Vol.9,Issue 1,April 2014 pp.37-41

Published: 30 April 2014

*Corresponding Author(s): DARJA PARO-PANJAN E-mail:


Neonatal seizures are the most frequent neurological disorder in the neonatal period. The incidence is reported to be higher than at any other period in life. Because of the unique nature of neonatal brain anatomy, connections and the paradoxical nature of neurotransmitters, seizures in this age group vary in semiology from those in older children. They may cause irreversible changes to the synapses in the immature brain and progress to epilepsy. 

The aim of the study was to analyse laboratory, clinical, neurophysiological and neuroimaging risk factors for epilepsy in a group of children who experienced seizures in the neonatal period.

A retrospective study of 176 newborns admitted to the Department of Neonatology, University Children’s Hospital Ljubljana, due to seizures, was performed. Metabolic disorders and hypoxic-ischaemic encephalopathy were the most frequent aeti-ological factors associated with seizures. Epilepsy rate in the group was 18%. Pathological cardiotocography, reanimation after delivery, myoclonic type of seizures, more than one type of seizures, severely abnormal electroencephalography, abnormal neurological examination and neuroimaging, treatment with more than one antiepileptic drug and duration of treatment more than one month constituted statistically significant independent predictive factors for epilepsy (p< 0.05). The results of our study further elucidate risk factors for epilepsy after neonatal seizures.


newborns, seizures, epi-lepsy, risk factors

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ANETA SOLTIROVSKA ŠALAMON ,DAVID NEUBAUER,DARJA PARO-PANJAN. Risk factors for developing epilepsy after neonatal seizures. Signa Vitae. 2014. 9(1);37-41.


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