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Invasive Candida infections in the nursery: state of the art


1Neonatology and NICU, S. Anna Hospital

2Infectious Diseases Unit, “G. Gaslini” Children’s Hospital

3Department of Paediatric Pharmacology and Pharmacogenetics, Clinical Investigation Centre Inserm CIC 9202 Hospital “Robert Debré”

4,Department of Paediatrics University of Torino

5Neonatology, IRCCS S

DOI: 10.22514/SV92.112014.1 Vol.9,Issue 2,November 2014 pp.5-8

Published: 03 November 2014

*Corresponding Author(s): PAOLO MANZONI E-mail:


Neonatal sepsis caused by fungi (mainly Candida spp.) causes a huge burden of morbidity and mortality, poor late outco-mes, as well as increased hospital costs. 

Invasive Candida Infections (ICI) include bloodstream, urine, cerebrospinal, peritoneal infections, infections starting from burns and wounds, or from any other usually sterile site.

Premature neonates are particularly prone to this kind of disease, due to their decreased innate and adaptive immunities, translating into a specific, decreased resistance to candidiasis.

This specific, increased risk for ICI is greatest when gestational age and birth weight are lowest. As the burden of ICI has been increasing over the last years, research efforts have been focused towards identifying key risk factors, effective pre-ventative strategies, and efficacious and well-tolerated antifungal drugs for the neonatal population.

This article summarizes the most remarkable issues in these areas, and features an overview of the current diagnostic, preventative and treatment strategies.


Candida, neonate, infecti-on, preterm, micafungin, fluconazole

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PAOLO MANZONI,ELIO CASTAGNOLA,EVELYNE JACQZ-AIGRAIN,MICHAEL MOSTERT,MAURO STRONATI,DANIELE FARINA. Invasive Candida infections in the nursery: state of the art. Signa Vitae. 2014. 9(2);5-8.


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