SepsEast and COVID-19: Time to Make a Difference

SepsEast is an enthusiastic intensivists group initiative launched in 2012, with the aim to facilitate clinical and research activities in the region. Through its actions and with the motto « Together we win, divided we are slow! » several joint research projects in the fields of perioperative medicine, fluid therapy, cardiovascular monitoring and support have been conducted. In the light of the COVID-19 pandemic, the SepsEast community is aware of its mission and is ready to take the challenge. This is mirrored by several educational, clinical and research activities including the development of a COVID-19 Registry; and an observational clinical study on cytokine adsorption in COVID-19 patients. The current pandemic should be our lesson on how to manage the global threat of infectious disease and to develop strategies for effective diagnostic and therapeutic procedures. Hopefully, the SepsEast community will contribute to these developments and scientific advances in general.

COVID-19, SARS-CoV-2, SepsEast

[1] Molnar Z. SepsEast: Bridging between East and West. J Crit Care. 2017;40:323.

[2] Kirov MY, Kuzkov VV, Molnar Z. Perioperative haemodynamic therapy. Curr Opin Crit Care. 2010;16:384-92.

[3] Salzwedel C, Puig J, Carstens A, et al. Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative compli-cations after major abdominal surgery: a multi-center, prospective, randomized study. Crit Care. 2013;17:R191.

[4] Lainscak M, Molnar Z, Monnet X, et al. Cardiovascular Function in Intensive Care Medicine or Homo Mensura Est. Biomed Res Int. 2016;2016:6301074.

[5] Benes J, Kirov M, Kuzkov V, et al. Fluid Therapy: Double-Edged Sword during Critical Care? Biomed Res Int. 2015;2015:729075.

[6] Molnár Z, Benes J, Reuter DA. Intensive care medicine in 2050: perioperative critical care. Intensive Care Med. 2017; 43:1138-1140.

[7] Molnar Z, Szabo Z, Nemeth M. Multimodal individualized concept of hemodynamic monitoring. Curr Opin Anaesthesiol. 2017;30:171-177.

[8] Rello J, Krenn CG, Locker G, et al. A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients. Crit Care. 2017;21:22.

[9] Ahmad T, Beilstein CM, Aldecoa C, et al. Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset. Perioper Med (Lond). 2015;4:8.

[10] Fauci AS, Lane HC, Redfield RR. Covid-19 - Navigating the Uncharted. N Engl J Med. 2020;382:1268-1269.

[11] Munster VJ, Koopmans M, van Doremalen N, et al. A Novel Coronavirus Emerging in China - Key Questions for Impact Assessment. N Engl J Med. 2020;382:692-694.

[12] Wang D, Hu B, Hu C. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020.

[13] ICNARC (Intensive Care National Audit and Research Centre) Case Mix Programme database report 24 April 2020 (www.icnarc.org).

[14] COVID-19 Clinical Research Coalition. Global coalition to acceler-ate COVID-19 clinical research in resource-limited settings. Lancet. 2020;395:1322-1325.

[15] Nemzeti Népegészségügyi Központ IV/3971-3/2020/EKU, 20.05.2020.

[16] https://tm-centre.org/hu/munkacsoportok/intenziv-tudomanyok-online-mindenkinek-ito-m-hu/, last viewed 5.5.2020.

[17] https://tm-centre.org/hu/munkacsoportok/mentorhalo-mentorterkep/, last viewed 5.5.2020.

[18] Nemzeti Népegészségügyi Központ IV/4568-1/2020/EKU, 22.05.2020.

[19] Inciardi RM, Lupi L, Zaccone G, et al. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA. 2020.

[20] Inciardi RM, Adamo M, Lupi L, et al. Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. Eur Heart J. 2020.

[21] Tavazzi G, Pellegrini C, Maurelli M, et al. Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail. 2020.

[22] Linschoten And M, Asselbergs FW. CAPACITY-COVID: a European registry to determine the role of cardiovascular disease in the COVID-19 pandemic. Eur Heart J. 2020.

[23] Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417-1418.

[24] Henry BM, de Oliveira MHS, Benoit S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020.

[25] Zeng Q, Li Yong-Zhe, Huang Hang, et al. Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population. Med Rxiv. 2020.

[26] Zhou F, Yu T, Du R, et al. Clinical Course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62.

[27] Zahorec R, Hulin I, Zahorec P. Rationale Use of Neutrophil-to-Lymphocyte Ratio for early diagnosis and stratification of COVID-19 . Brat Med J. 2020.

[28] Čelutkienė J, Lainscak M, Anderson L, et al. Imaging in patients with suspected acute heart failure: timeline approach position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020;22:181-195.

[29] Čelutkienė J, Plymen CM, Flachskampf FA, et al. Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018;20:1615-1633.

[30] Harjola VP, Parissis J, Brunner-La Rocca HP, et al. Comprehensive in-hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail. 2018;20:1081-1099.

[31] Ovsenik A, Fabijan A, Bervar M, et al. Can echocardiographic assessment of interatrial septum shape and motion improve the accuracy of the BLUE protocol? Signa Vitae. 2019;15:18-22.

[32] Šustić M, Šustić A. Unrecognized B line mimicked pneumothorax on M mode ultrasound. Signa Vitae. 2018;14:92.

[33] Cao B, Wang Y, Wen D, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020.