Article Data

  • Views 5594
  • Dowloads 359


Open Access

SepsEast and COVID-19: Time to Make a Difference

  • Mitja Lainscak1,2
  • Alan Sustic3,4
  • Jan Benes5,6
  • Miroslaw Czuczwar7
  • Radmilo Jankovic8
  • Mikhail Kirov9
  • Roman Kula10
  • Krzysztof Kusza11
  • Matej Podbregar2,12
  • Dorel Sandesc13
  • Ovidiu Bedreag13
  • Konstanty Szuldrzynski14
  • Roman Zahorec15
  • Peter Hegyi16
  • Zsolt Molnar11,16

1Division of Cardiology, General Hospital Murska Sobota, Murska Sobota, Slovenia

2Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

3Department of Anesthesiology, Reanimatology, Intensive Care and Emergency Medicine, Faculty of Medicine, University of Rijeka, Rijeka, Croatia

4Department of Clinical Medical Science II, Faculty of Health Studies, University of Rijeka, Rijeka, Croatia

5Department of Anesthesiology and Intensive Care, Faculty of Medicine in Plzen, Charles University, Czech Republic

6Biomedical center, Faculty of Medicine in Plzen, Charles University, Czech Republic

72nd Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland

8Clinic for Anesthesiology and Intensive Care, Clinical Center Nis, School of Medicine, University of Nis, Serbia

9Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation

10Departement of Anesthesiology and Intensive Care, University Hospital Ostrava, Czech Republic

11Department of Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Faculty of Medicine, Poznan, Poland

12Department for internal intensive care, General and Teaching Hospital Celje, Slovenia

13"V. Babes" University of Medicine and Pharmacy, Timisoara, Romania

14Department of Interdisciplinary Intensive Care Jagiellonian University Medical College, Krakow, Poland

15Department of Anesthesiology and Intensive Medicine, Comenius University, Bratislava, Slovakia

16Institute for Translational Medicine, School of Medicine, University of Pécs, Pécs, Hungary

DOI: 10.22514/sv.2020.16.0001 Vol.16,Issue 1,June 2020 pp.1-4

Published: 30 June 2020

*Corresponding Author(s): Mitja Lainscak E-mail:
*Corresponding Author(s): Zsolt Molnar E-mail:


SepsEast is an enthusiastic intensivists group initiative launched in 2012, with the aim to facilitate clinical and research activities in the region. Through its actions and with the motto « Together we win, divided we are slow! » several joint research projects in the fields of perioperative medicine, fluid therapy, cardiovascular monitoring and support have been conducted. In the light of the COVID-19 pandemic, the SepsEast community is aware of its mission and is ready to take the challenge. This is mirrored by several educational, clinical and research activities including the development of a COVID-19 Registry; and an observational clinical study on cytokine adsorption in COVID-19 patients. The current pandemic should be our lesson on how to manage the global threat of infectious disease and to develop strategies for effective diagnostic and therapeutic procedures. Hopefully, the SepsEast community will contribute to these developments and scientific advances in general.


COVID-19, SARS-CoV-2, SepsEast

Cite and Share

Mitja Lainscak,Alan Sustic,Jan Benes,Miroslaw Czuczwar,Radmilo Jankovic,Mikhail Kirov,Roman Kula,Krzysztof Kusza,Matej Podbregar,Dorel Sandesc,Ovidiu Bedreag,Konstanty Szuldrzynski,Roman Zahorec,Peter Hegyi,Zsolt Molnar. SepsEast and COVID-19: Time to Make a Difference. Signa Vitae. 2020. 16(1);1-4.


[1] Molnar Z. SepsEast: Bridging between East and West. J Crit Care. 2017;40:323.

[2] Kirov MY, Kuzkov VV, Molnar Z. Perioperative haemodynamic therapy. Curr Opin Crit Care. 2010;16:384-92.

[3] Salzwedel C, Puig J, Carstens A, et al. Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces postoperative compli-cations after major abdominal surgery: a multi-center, prospective, randomized study. Crit Care. 2013;17:R191.

[4] Lainscak M, Molnar Z, Monnet X, et al. Cardiovascular Function in Intensive Care Medicine or Homo Mensura Est. Biomed Res Int. 2016;2016:6301074.

[5] Benes J, Kirov M, Kuzkov V, et al. Fluid Therapy: Double-Edged Sword during Critical Care? Biomed Res Int. 2015;2015:729075.

[6] Molnár Z, Benes J, Reuter DA. Intensive care medicine in 2050: perioperative critical care. Intensive Care Med. 2017; 43:1138-1140.

[7] Molnar Z, Szabo Z, Nemeth M. Multimodal individualized concept of hemodynamic monitoring. Curr Opin Anaesthesiol. 2017;30:171-177.

[8] Rello J, Krenn CG, Locker G, et al. A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients. Crit Care. 2017;21:22.

[9] Ahmad T, Beilstein CM, Aldecoa C, et al. Variation in haemodynamic monitoring for major surgery in European nations: secondary analysis of the EuSOS dataset. Perioper Med (Lond). 2015;4:8.

[10] Fauci AS, Lane HC, Redfield RR. Covid-19 - Navigating the Uncharted. N Engl J Med. 2020;382:1268-1269.

[11] Munster VJ, Koopmans M, van Doremalen N, et al. A Novel Coronavirus Emerging in China - Key Questions for Impact Assessment. N Engl J Med. 2020;382:692-694.

[12] Wang D, Hu B, Hu C. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020.

[13] ICNARC (Intensive Care National Audit and Research Centre) Case Mix Programme database report 24 April 2020 (

[14] COVID-19 Clinical Research Coalition. Global coalition to acceler-ate COVID-19 clinical research in resource-limited settings. Lancet. 2020;395:1322-1325.

[15] Nemzeti Népegészségügyi Központ IV/3971-3/2020/EKU, 20.05.2020.

[16], last viewed 5.5.2020.

[17], last viewed 5.5.2020.

[18] Nemzeti Népegészségügyi Központ IV/4568-1/2020/EKU, 22.05.2020.

[19] Inciardi RM, Lupi L, Zaccone G, et al. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA. 2020.

[20] Inciardi RM, Adamo M, Lupi L, et al. Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy. Eur Heart J. 2020.

[21] Tavazzi G, Pellegrini C, Maurelli M, et al. Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail. 2020.

[22] Linschoten And M, Asselbergs FW. CAPACITY-COVID: a European registry to determine the role of cardiovascular disease in the COVID-19 pandemic. Eur Heart J. 2020.

[23] Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417-1418.

[24] Henry BM, de Oliveira MHS, Benoit S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020.

[25] Zeng Q, Li Yong-Zhe, Huang Hang, et al. Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population. Med Rxiv. 2020.

[26] Zhou F, Yu T, Du R, et al. Clinical Course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62.

[27] Zahorec R, Hulin I, Zahorec P. Rationale Use of Neutrophil-to-Lymphocyte Ratio for early diagnosis and stratification of COVID-19 . Brat Med J. 2020.

[28] Čelutkienė J, Lainscak M, Anderson L, et al. Imaging in patients with suspected acute heart failure: timeline approach position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020;22:181-195.

[29] Čelutkienė J, Plymen CM, Flachskampf FA, et al. Innovative imaging methods in heart failure: a shifting paradigm in cardiac assessment. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018;20:1615-1633.

[30] Harjola VP, Parissis J, Brunner-La Rocca HP, et al. Comprehensive in-hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail. 2018;20:1081-1099.

[31] Ovsenik A, Fabijan A, Bervar M, et al. Can echocardiographic assessment of interatrial septum shape and motion improve the accuracy of the BLUE protocol? Signa Vitae. 2019;15:18-22.

[32] Šustić M, Šustić A. Unrecognized B line mimicked pneumothorax on M mode ultrasound. Signa Vitae. 2018;14:92.

[33] Cao B, Wang Y, Wen D, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19. N Engl J Med. 2020.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,200 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

Index Copernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus: CiteScore 1.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time