Article Data

  • Views 435
  • Dowloads 27

Original Research

Open Access

Sex Differences in Risk Factors Associated with Coronary Artery Disease: What Does Glycated Albumin Indicate?

  • Lin Sun1
  • Haitao Yuan1

1Department of Cardiovascular Disease, Shandong Provincial Hospital affiliated to Shandong University, Jinan, P.R. China

DOI: 10.22514/sv.2020.16.0018 Vol.16,Issue 1,June 2020 pp.137-145

Published: 30 June 2020

*Corresponding Author(s): Haitao Yuan E-mail: yhtsdsl@163.com

PDF (537.05 kB)

Abstract

Objective: To investigate gender differences in risk factors associated with coronary artery disease (CAD), and to explore the association between glycated albumin (GA) and CAD. Method: We recruited 350 adult patients, collected their clinical information and divided them into CAD and non-CAD groups, based on angiography results. Results: Patients with CAD showed significantly higher age related GA, fasting blood glucose, serum creatinine (SCr) and Gensini score. Multivariate Logistic regression analysis identified gender, age, superoxide dismutase(SOD) and GA as independent factors in CAD patients (p < 0.05) and the mean GA level in females was higher than in males. Univariate linear regression analysis also showed that GA was not associated with male CAD patients. In females, SOD, low-density lipoprotein cholesterol (LDL-c), and GA were associated with a significant Gensini score (p < 0.05). Finally, GA was capable of classifying CAD in women (AUC > 0.767; p < 0.001). Conclusion: GA is positively correlated with the severity of coronary artery obstruction in female patients presenting with CAD.

Key words

Coronary artery disease, Angiography, Gensini score, Glycated albumin

Cite And Share

Lin Sun,Haitao Yuan. Sex Differences in Risk Factors Associated with Coronary Artery Disease: What Does Glycated Albumin Indicate?. Signa Vitae. 2020. 16(1);137-145.

References

[1] Yahagi K, Kolodgie FD, Lutter C, et al. Pathology of Human Coro-nary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2017;37:191-204.

[2] N.H. Cho, J.E. Shaw, S. Karuranga, et al. Global estimates of diabetes prevalence for 2017 and projections for 2045. IDF Diabetes Atlas. 2018;138:271-81.

[3] Ma X, Hu X, Zhou J, et al. Glycated albumin is more closely correlated with coronary artery disease than 1,5-anhydroglucitol and glycated hemoglobin A1c. Cardiovasc Diabetol. 2015;14:16.

[4] Selvin E, Rawlings AM, Lutsey PL, et al. Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death. Circulation. 2015;132:269-77.

[5] Ryan TJ, Faxon DP, Gunnar RM, et al. Guidelines for percutaneous transluminal coronary angioplasty. A report of the American College of Cardiology/American Heart Association Task Force on Assess-ment of Diagnostic and Therapeutic Cardiovascular Procedures (Sub-committee on Percutaneous Transluminal Coronary Angioplasty). J Am Coll Cardiol. 1988;12:529-45.

[6] Ma YC, Zuo L, Chen JH, et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol. 2006;17:2937–44.

[7] Alan B, Akpolat V, Aktan A, et al. Relationship between osteopenic syndrome and severity of coronary artery disease detected with coronary angiography and Gensini score in men. Clin Interv Aging. 2016;11:377-82.

[8] Vouillarmet J, Marsot C, Maucort-Boulch D, et al. Vascular Events and Carotid Atherosclerosis: A 5-Year Prospective Cohort Study in Patients with Type 2 Diabetes and a Contemporary Cardiovascular Prevention Treatment. J Diabetes Res. 2019:9059761.

[9] Song SO, Kim K J, Lee BW, et al. Serum glycated albumin predicts the progression of carotid arterial atherosclerosis. Atherosclerosis. 2012;225:450-5.

[10] Lee AS, Chen WY, Chan HC, et al. Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovasc Diabetol. 2014;13:64.

[11] Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease. Biochem Pharmacol. 2013;86:1627-42.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) The Science Citation Index (SCI) is a citation index originally produced by the Institute for Scientific Information (ISI) and created by Eugene Garfield. It (Science Citation Index Expanded) covers more than 8,500 notable and significant journals, across 150 disciplines in science and technology, from 1900 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Chemical Abstracts Service Source Index The CAS Source Index (CASSI) Search Tool is an online resource that can quickly identify or confirm journal titles and abbreviations for publications indexed by CAS since 1907, including serial and non-serial scientific and technical publications.

IndexCopernicus The Index Copernicus International (ICI) Journals database’s is an international indexation database of scientific journals. It covered international scientific journals which divided into general information, contents of individual issues, detailed bibliography (references) sections for every publication, as well as full texts of publications in the form of attached files (optional). For now, there are more than 58,000 scientific journals registered at ICI.

Geneva Foundation for Medical Education and Research The Geneva Foundation for Medical Education and Research (GFMER) is a non-profit organization established in 2002 and it works in close collaboration with the World Health Organization (WHO). The overall objectives of the Foundation are to promote and develop health education and research programs.

Scopus Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Embase Embase (often styled EMBASE for Excerpta Medica dataBASE), produced by Elsevier, is a biomedical and pharmacological database of published literature designed to support information managers and pharmacovigilance in complying with the regulatory requirements of a licensed drug.

Submission Turnaround Time

Conferences

    Top