Sex Differences in Risk Factors Associated with Coronary Artery Disease: What Does Glycated Albumin Indicate?

Objective: To investigate gender differences in risk factors associated with coronary artery disease (CAD), and to explore the association between glycated albumin (GA) and CAD. Method: We recruited 350 adult patients, collected their clinical information and divided them into CAD and non-CAD groups, based on angiography results. Results: Patients with CAD showed significantly higher age related GA, fasting blood glucose, serum creatinine (SCr) and Gensini score. Multivariate Logistic regression analysis identified gender, age, superoxide dismutase(SOD) and GA as independent factors in CAD patients (p < 0.05) and the mean GA level in females was higher than in males. Univariate linear regression analysis also showed that GA was not associated with male CAD patients. In females, SOD, low-density lipoprotein cholesterol (LDL-c), and GA were associated with a significant Gensini score (p < 0.05). Finally, GA was capable of classifying CAD in women (AUC > 0.767; p < 0.001). Conclusion: GA is positively correlated with the severity of coronary artery obstruction in female patients presenting with CAD.

Coronary artery disease, Angiography, Gensini score, Glycated albumin

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