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Deep Vein Thrombosis in Non-ICU COVID-19 Patients: An Additional Risk

  • Sohil Pothiawala1

1Department of Emergency Medicine, Woodlands Health Campus, Singapore

DOI: 10.22514/sv.2020.16.0024 Vol.16,Issue 1,June 2020 pp.179-181

Published: 30 June 2020

*Corresponding Author(s): Sohil Pothiawala E-mail:


Introduction: Venous thromboembolism (VTE) encompasses two conditions, deep vein thrombosis (DVT) and pulmonary embolism (PE). Patients admitted to the intensive care unit (ICU) are at highest thrombotic risk. The incidence of VTE in COVID-19 patients is not definitely established, with studies reporting an incidence rate of 25 - 27%. Discussion: As the COVID-19 pandemic progresses, studies are reporting increased incidence of VTE in COVID-19 patients admitted in ICU. But there are not many studies reporting the incidence of DVT in non-ICU COVID-19 patients. Elevated levels of D-dimer indicate hypercoagulability, but it can also indicate inflammation. 68% of hospitalized COVID-19 patients had elevated D-dimer levels. Thus, D-dimer level at the time of admission does not co-relate with the development of VTE or its related complications in COVID-19 patients. One study reported that out of the total number of non-ICU COVID-19 patients who had signs or symptoms suggestive of DVT, 50% were detected to be positive on compression ultrasound scan. While some studies and international guidelines recommend the administration of LMWH in all hospitalized COVID-19 patients, some studies recommend that the physicians should closely monitor patients for development of signs and symptoms of DVT, and perform prompt diagnostic tests to aid early diagnosis and initiate anticoagulation. Hence, the treatment protocols vary widely across institutions, and the decision of thromboprophylaxis is also made on a case-by-case basis. Conclusion: Further studies are needed to establish the incidence of DVT in non-ICU patients, the predictive value of d-dimer levels to detect DVT risk, and an optimal therapeutic regimen of prophylactic anti-coagulant therapy in these patients.


COVID-19, Deep vein thrombosis, Non-ICU, Incidence

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Sohil Pothiawala. Deep Vein Thrombosis in Non-ICU COVID-19 Patients: An Additional Risk. Signa Vitae. 2020. 16(1);179-181.


[1] Levi M, Scully M. How I treat disseminated intravascular coagula-tion. Blood. 2018;131:845-854.

[2] Cook DJ, Crowther MA, Meade MO, et al. VTE in the ICU workshop participants. Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients. J Crit Care. 2005;20:309-13.

[3] Cui S, Chen S, Li X, et al. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18:1421-1424.

[4] Klok FA, Kruip MJHA, Van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-

19. Thromb Res. 2020;191:145-147.

[5] Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395:1054-1062.

[6] Connors JM, Levy JH. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020;135:2033–2040.

[7] Thachil J, Tang N, Gando S, et al. International Society on Thrombosis and Haemostasis (ISTH) interim guidance on recognition and management of coagulopathy in COVID‐19. J Thromb Haemost. 2020;18:1023-1026.

[8] Criel M, Falter M, Jaeken J, et al. Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it? Eur Respir J. 2020.

[9] Grillet F, Behr J, Calame P, et al. Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography. Radiology. 2020.

[10] Marone E., Rinaldi L. Upsurge of deep venous thrombosis in patients affected by COVID-19: Preliminary data and possible explanations. J Vasc Surg Venous Lymphat Disord. 2020.

[11] Spyropoulos AC, Levy JH, Ageno W, et al. Scientific and Stan-dardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID‐19. J Thromb Haemostat. 2020.

[12] American Society of Hematology. COVID-19 and Coagulopa-thy: Frequently Asked Questions. accessable on: https://www.

[13] Porfidia A, Pola R. Venous thromboembolism and heparin use in COVID-19 patients: juggling between pragmatic choices, sugges-tions of medical societies. J Thromb Thrombolysis. 2020.

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