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Original Research

Open Access

The New Markers of Ventricular Dispersion in Patients with Acute Poisoning with TCAs: Tp-e Interval and Tp-e/QTc Ratio

  • Akkan Avci1
  • Mehmet Uzucek1
  • Satuk BugraYapici1
  • Begum Seyda Avci2
  • Onder Yesiloglu1
  • Hayri Cinar1
  • Ferhat Icme3
  • Salim Satar1

1Department of Emergency Medicine, Adana City Research and Training Hospital, Health Science University, Adana, Turkey

2Department of Internal Medicine, Adana City Research and Training Hospital, Health Science University, Adana, Turkey

3Department of Emergency Medicine, Ankara City Hospital, Ankara, Turkey

DOI: 10.22514/sv.2020.16.0044 Vol.17,Issue 1,January 2021 pp.124-127

Published: 08 January 2021

*Corresponding Author(s): Akkan Avci E-mail:


Introduction: Purpose of this study was to investigate the changes in Tp-e/QTc rates and Tp-e intervals in patients poisoned with tricyclic antidepressants. Methods: 187 patients who were poisoned with tricyclic antidepressants and admitted to our emergency department were included in this study. Control group consisted of 187 healthy individuals with similar age and gender characteristics. All patients underwent 12-lead electrocardiograms (ECG). In addition to QTc measurement, Tp-e/QTc ratios and Tp-e interval were measured in the ECG. Study data were divided two groups as patients and healthy controls. Results: It was found that the QTc interval, Tp-e interval, and Tp-e/QTc ratio were significantly higher in the patient group compared to control group. The analysis demonstrated that QTc interval; Tp-e interval and Tp-e/QTc ratio were independently associated with heart rate. Conclusion: In poisoning with TCAs, the rate of QTc interval, Tp-e/QTc and Tp-e interval has increased and is independently associated with the heart rate in these patients. This may be the precursor of possible fatal ventricular arrhythmias in tricyclic antidepressants.


Tricyclic antidepressants, QTc interval, Tp-e/QTc ratio Tp-e interval, Emergency medicine

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Akkan Avci,Mehmet Uzucek,Satuk BugraYapici,Begum Seyda Avci,Onder Yesiloglu,Hayri Cinar,Ferhat Icme,Salim Satar. The New Markers of Ventricular Dispersion in Patients with Acute Poisoning with TCAs: Tp-e Interval and Tp-e/QTc Ratio. Signa Vitae. 2021. 17(1);124-127.


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