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Original Research

Open Access

Outcomes of M. pneumoniae pneumonia with mixed infection

  • Cheng-Yi Wang1,2
  • Lu-Min Chen1
  • Guang-Hua Liu1
  • Shi-Biao Wang3
  • Qi-Qi Lin4

1Department of Pediatrics, Fujian Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China

2Engineering Research Center for Medical Data Mining and Application of Fujian Province, Xiamen, P. R. China

3Pediatric Intensive Care Unit, Fujian Maternity and Children Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, P. R. China

4Class 4, Grade 2018, Fujian Medical University, Fuzhou, P. R. China

DOI: 10.22514/sv.2020.16.0087 Vol.17,Issue 2,March 2021 pp.160-167

Published: 08 March 2021

*Corresponding Author(s): Lu-Min Chen E-mail:


Background: Mycoplasma pneumoniae pneumonia (MPP) is often complicated with mixed infections that worsen the prognosis, but the outcomes in pediatric cases are unclear. The aim of this study is to investigate the association of mixed infection and outcomes in severe MPP that occurs in childhood.

Methods: This retrospective study included 184 pediatric cases of severe MPP that were managed at our hospital (between January 2014 and December 2017). The cohort was divided into the single Mycoplasma pneumoniae infection, mixed infection with a noxa other than M. pneumoniae, and mixed infection with two or more noxae other than M. pneumoniae groups. The demographic and clinical information of the patients was compared via statistical analysis.

Results: The incidence of mixed infections was high at 64.1%. Cytomegalovirus and Epstein-Barr virus were the most common causes of mixed infection. According to the findings of binary logistic regression analysis, the presence of more than one pathogen (other than M. pneumoniae) was positively associated with the score determined from Pediatric Risk of Mortality III (β = 0.760, odds ratio [OR] = 2.139, 95% confidence interval [CI] = 1.391-2.390, P = 0.001), Pediatric Critical Illness Score (β = 1.203, OR = 3.328, 95% CI = 1.723-6.731, P = 0.000), and total length of hospital stay (β = 0.730, OR = 2.075, 95% CI = 1.404-3.066, P = 0.000).

Conclusion: Viral and bacterial mixed infection in pediatric cases of severe MPP is positively associated with hospitalization period and disease severity, and ultimately, may increase the chances of severe illness and death among children.


Mycoplasma pneumonia; Severity; Mixed infection; PRISM III; PCIS; Retrospective

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Cheng-Yi Wang,Lu-Min Chen,Guang-Hua Liu,Shi-Biao Wang,Qi-Qi Lin. Outcomes of M. pneumoniae pneumonia with mixed infection. Signa Vitae. 2021. 17(2);160-167.


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