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Original Research

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Transcutaneous electrical acupoint stimulation before induction of anesthesia reduces sufentanil-induced cough: a randomized, controlled trial

  • Jun-Jie Xie1
  • Yun-Chang Mo1
  • Jun-Kai Wang2
  • Li-Li Yang3
  • Hai-Juan He4
  • Jun-Lu Wang1

1Department of Anesthesiology of First Affiliated Hospital of Wenzhou Medical University, P. R. China

2Department of Anesthesiology of Zhejiang Provincial People’s Hospital, P. R. China

3Department of Anesthesiology of Central Hospital of Lishui, P. R. China

4Department of Anesthesiology of Taizhou Hospital of Zhejiang Province, P. R. China

DOI: 10.22514/sv.2021.024 Vol.17,Issue 4,July 2021 pp.66-70

Submitted: 21 December 2020 Accepted: 19 January 2021

Published: 08 July 2021

*Corresponding Author(s): Jun-Lu Wang E-mail:


Background: Sufentanil-induced cough is a common side effect during the induction of general anesthesia. This study sought to determine the inhibitory effect of TEAS (transcutaneous electrical acupoint stimulation) on the incidence of sufentanil-induced cough.

Methods: A total of 339 patients were recruited of which 300 patients were enrolled and randomly allocated into five groups (n = 60): Patients did not receive TEAS in the control group (C group); patients received 2 Hz TEAS at LI4/PC6 (Hegu/Neiguan) in the 2A group; patients received 100 Hz TEAS at LI4/PC6 in the 100A group; patients received 2 Hz TEAS at ST36/SP6 (Zusanli/sanyinjiao) in the 2B group; and patients received 100 Hz TEAS at ST36/SP6 in the 100B group. With the exception of the C group, all groups received TEAS for 30 minutes before induction. 0.5 µg/kg of IV sufentanil was given over 2 seconds, and the occurrence of cough was observed and recorded for 1 minute. The severity of cough was graded as mild (1-2 coughs), moderate (3-5 coughs), and severe (> 5 coughs). The mean arterial pressure (MAP) and heart rate (HR) before (T0) and 1 minute after (T1) sufentanil injection were recorded.

Results: The incidence of sufentanil-induced cough in C group, 2A group, 2B group, 100A group and 100B group were 37%, 27%, 27%, 12% and 13%, respectively. Compared with the C group, the incidence of cough in the 100A group and the 100B group were significantly lower (P < 0.05). The MAP and HR between the five groups were not statistically different.

Conclusion: The administration of 100 Hz TEAS for 30 minutes before sufentanil injection can effectively reduce the incidence of sufentanil-induced cough during the induction of general anesthesia.


Sufentanil; Cough; TEAS; General anesthesia

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Jun-Jie Xie,Yun-Chang Mo,Jun-Kai Wang,Li-Li Yang,Hai-Juan He,Jun-Lu Wang. Transcutaneous electrical acupoint stimulation before induction of anesthesia reduces sufentanil-induced cough: a randomized, controlled trial. Signa Vitae. 2021. 17(4);66-70.


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